骨质疏松与遗传的研究近况

被引：5

作者：

张钰聪

机构：

[1] 首都医科大学宣武医院内科

来源：

关键词：

骨质疏松; 维生素D受体; Ⅰ型胶原; 雌激素受体; 转移生长因子β; 降钙素; 胰岛素样生长因子;

D O I：

暂无

中图分类号：

R580 [];

学科分类号：

摘要：

骨质疏松症是一种老年性常见病,与众多因素相关,而遗传是其中的重要因素。本文从遗传学角度简要综述了近几年来国内外对维生素D受体基因、胶原基因、雌激素受体基因、转移生长因子β基因、降钙素受体基因等基因多态性与骨质疏松之间关系的研究,为骨质疏松的早期诊断以及采取进一步治疗奠定基础。

引用

页码：1 / 5

页数：5

共 4 条

[1] Polymorphism at the Sp 1 binding site in the collagen type I α 1 gene does not predict bone mineral density in postmenopausal women in Sweden
Lidén, M
Wilén, B
Ljunghall, S
Melhus, H
[J]. CALCIFIED TISSUE INTERNATIONAL, 1998, 63 (04) : 293 - 295
[2] Polymorphism of insulin-like growth factor I gene and bone mineral density
Miyao, M
Hosoi, T
Inoue, S
Hoshino, S
Shiraki, M
Orimo, H
Ouchi, Y
[J]. CALCIFIED TISSUE INTERNATIONAL, 1998, 63 (04) : 306 - 311
[3] Correlation Between Vitamin D Receptor Genotypes and Bone Mineral Density in Japanese Patients with Osteoporosis[J] . M. Tamai,M. Yokouchi,S. Komiya,K. Mochizuki,S. Hidaka,S. Narita,A. Inoue,K. Itoh.Calcified Tissue International . 1997 (3)
[4] INVESTIGATION OF THE RELATIONSHIP BETWEEN OSTEOPOROSIS AND THE COLLAGENASE GENE BY MEANS OF POLYMORPHISM OF THE 5'UPSTREAM REGION OF THIS GENE
THIRYBLAISE, LM
TAQUET, AN
REGINSTER, JY
NUSGENS, B
FRANCHIMONT, P
LAPIERE, CM
[J]. CALCIFIED TISSUE INTERNATIONAL, 1995, 56 (01) : 88 - 91