丁丙诺啡的药理学研究进展

被引：6

作者：

张开镐

机构：

[1] 北京大学中国药物依赖性研究所药理教研室

来源：

国际药学研究杂志 | 2010年 / 37卷 / 03期

关键词：

丁丙诺啡; 阿片受体; 镇痛作用; 呼吸抑制; 免疫抑制;

D O I：

10.13220/j.cnki.jipr.2010.03.007

中图分类号：

R96 [药理学];

学科分类号：

100602 ; 100706 ;

摘要：

丁丙诺啡是半合成的阿片生物碱蒂巴因的衍生物,对阿片受体家族的4个成员μ、κ、δ和ORL-1都有一定的亲和力,但内在活性不同;同时,与这些受体具有缓慢结合与分离的动力学特征,决定了它有一些不同于其他μ阿片受体激动剂的药理特性。本文介绍近期对丁丙诺啡药理特性进一步研究的资料,以期对丁丙诺啡临床应用的有效性和安全性有新的认识。

引用

页码：161 / 164

页数：4

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