天然免疫系统非克隆识别机制的进展

被引:6
作者
王伯瑶
吴琦
黄宁
机构
[1] 华西医科大学感染免疫研究室
[2] 华西医科大学感染免疫研究室 成都
[3] 成都
关键词
天然免疫; 识别机制; 共刺激作用;
D O I
10.16262/j.cnki.1000-8217.1999.04.005
中图分类号
R392 [医学免疫学];
学科分类号
100102 ;
摘要
本文综述了高等动物存在两大相互依存、相互作用的完整的抗感染防御系统,即天然免疫的非克隆识别机制和以克隆选择为基础的获得性免疫。天然免疫的非克隆识别机制诱导抗原提呈细胞表达共刺激因子,触发获得性免疫反应,并通过释放细胞因子引导获得性免疫系统发生特异的免疫效应反应。在天然免疫反应中,通过胚胎细胞编码的受体识别病原体几种特有的保守分子,诱导天然免疫细胞表达抗菌肽、共刺激因子和效应细胞因子。认识天然免疫识别的分子机制,在疫苗设计和发展免疫治疗新举措上,意义重大。
引用
收藏
页码:18 / 21
页数:4
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