血小板激活因子拮抗剂WEB2086对小鼠腹腔巨噬细胞释放肿瘤坏死因子的影响(英文)

被引:2
作者
鞠佃文
郑钦岳
王洪斌
王晓峰
方军
不详
机构
[1] 第二军医大学药学院药理教研室
[2] 第二军医大学药学院药理教研室 上海
[3] 上海
关键词
肿瘤坏死因子; 巨噬细胞; 血小板激活因子拮抗剂WEB 2086;
D O I
10.16438/j.0513-4870.1993.10.001
中图分类号
学科分类号
摘要
小鼠ip3%TG 4天后取其腹腔巨噬细胞,血小板激活因子拮抗剂WEB 2086对LPS诱导的巨噬细胞释放肿瘤坏死因子(TNF)有显著的抑制作用。时效研究表明,TNF的产生和WEB 2086的抑制作用从LPS刺激后4 h开始,持续到22 h,在16 h时达到高峰。本文还首次采用一种用放线菌素D和NaF处理的L-929细胞测定TNF的新方法,此法与另外3种生物测定方法进行比较的结果显示此法具有更敏感、方便的特点。
引用
收藏
页码:721 / 727
页数:7
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