Sodium arsenite reduces severity of dextran sulfate sodium-induced ulcerative colitis in rats

被引：3

作者：

Joshua J MALAGO ^{[1
]}

Hortensia NONDOLI ^{[2
]}

机构：

[1] Department of Pathology Faculty of Veterinary Medicine, Sokoine University of Agriculture, PO Box , Morogoro, Tanzania,

[2] Regional Immigration Office PO Box , Mtwara, Tanzania

来源：

Journal of Zhejiang University(Science B:An International Biomedicine & Biotechnology Journal) | 2008年 / 04期

关键词：

D O I：

暂无

中图分类号：

R365 [临床病理学（系统及内脏病理学）];

学科分类号：

100231 [临床病理学];

摘要：

The histopathological features and the associated clinical findings of ulcerative colitis (UC) are due to persistent inflammatory response in the colon mucosa. Interventions that suppress this response benefit UC patients. We tested whether sodium arsenite (SA) benefits rats with dextran sulfate sodium (DSS)-colitis. The DSS-colitis was induced by 5% DSS in drinking water. SA (10 mg/kg; intraperitoneally) was given 8 h before DSS treatment and then every 48 h for 3 cycles of 7, 14 or 21 d. At the end of each cycle rats were sacrificed and colon sections processed for histological examination. DSS induced diarrhea, loose stools, hemoccult positive stools, gross bleeding, loss of body weight, loss of epithelium, crypt damage, depletion of goblet cells and infiltration of inflammatory cells. The severity of these changes increased in the order of Cycles 1, 2 and 3. Treatment of rats with SA significantly reduced this severity and improved the weight gain.

引用

页码：341 / 350

页数：10

共 13 条

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