齐墩果醇酸对化学物质致小鼠急性肝损伤的保肝作用(英文)

被引：10

作者：

刘杰

刘亚平

Curtis D KLAASSEN

机构：

[1] University of Kansas Medical Center

[2] Kansas City KS - USA

来源：

ActaPharmacologicaSinica | 1995年 / 02期

关键词：

齐墩果醇酸; 肝; 四氯化碳中毒; 醋氨酚; 溴化苯类; 鬼笔毒环肽; 镉中毒; 半乳糖胺; 内毒素; 硫代乙酰胺;

D O I：

暂无

中图分类号：

R96 [药理学];

学科分类号：

100602 ; 100706 ;

摘要：

目的:评价齐墩果醇酸（OA）对急性肝损伤的保肝作用.方法:小鼠sc OA 200 μmol·kg-1三天,然后给予肝毒物.通过病理组织学观察及测定血清丙氨酸转氨酶和艾杜糖醇脱氢酶活性来估价肝损伤.结果:OA能明显减轻四氯化碳,溴苯,醋氨酚,速尿,硫代乙酰胺,鬼笔毒环肽,秋水仙硷,氯化镉,D—半乳糖胺和内毒素等所致小鼠急性坏死性肝损伤,降低这些肝毒物所引起的血清转氨酶和艾杜糖醇脱氢酶的升高,但对氯仿,二甲亚硝氨,鹅膏菌索和烯丙醇的毒性无作用.结论:OA能减轻多种化学物质（但并非全部）引起的肝损伤.其保肝机制可能是多方面的.

引用

页码：3 / 8+99

页数：7

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