药物与辅料相容性研究进展

被引：51

作者：

曹筱琛 ^{[1
]}

贾飞 ^{[2
]}

陶巧凤 ^{[1
,2
]}

机构：

[1] 浙江工业大学药学院

[2] 浙江省食品药品检验研究院

来源：

中国现代应用药学 | 2013年 / 30卷 / 02期

关键词：

药物-辅料相互作用; 相容性; 热分析法; 光谱法; 色谱法;

D O I：

10.13748/j.cnki.issn1007-7693.2013.02.007

中图分类号：

R943 [制剂学];

学科分类号：

100702 [药剂学];

摘要：

目的对药物与辅料的相容性及相互作用机制和研究方法进展作概述和分析。方法结合近年来国内外相关文献进行评述和展望。结果药物与辅料的相互作用可改变药物活性分子的理化性质,影响药物的稳定性和有效性。结论药物与辅料的相容性研究对制剂处方设计、提高制剂质量和安全性至关重要,药物与辅料相容性及作用机制研究的方法有热分析法、光谱法、色谱法等,可根据试验目的和要求选择适宜的分析方法。

引用

收藏

页码：223 / 228

页数：6

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