正确认识生物标记物在全身性感染诊治中的价值

被引:5
作者
杨毅
邱海波
机构
[1] 东南大学附属中大医院重症医学科
关键词
D O I
暂无
中图分类号
R459.7 [急症、急救处理];
学科分类号
100231 [临床病理学];
摘要
<正>尽管抗生素以及复苏治疗近年来取得了长足的进步,全身性感染仍然是导致重症患者死亡的重要原因,病死率高达30%~70%。早期积极治疗对于改善感染患者预后具有重要临床意义。要想实现早期治疗,早期的诊断就显得十分重要和必要。
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[1]
Procalcitonin-guided interventions against infections to increase early appropriate antibiotics and improve survival in the intensive care unit: A randomized trial [J].
Jensen, Jens U. ;
Hein, Lars ;
Lundgren, Bettina ;
Bestle, Morten H. ;
Mohr, Thomas T. ;
Andersen, Mads H. ;
Thornberg, Klaus J. ;
Loken, Jesper ;
Steensen, Morten ;
Fox, Zoe ;
Tousi, Hamid ;
Soe-Jensen, Peter ;
Lauritsen, Anne O. ;
Strange, Ditte ;
Petersen, Pernille L. ;
Reiter, Nanna ;
Hestad, Soren ;
Thormar, Katrin ;
Fjeldborg, Paul ;
Larsen, Kim M. ;
Drenck, Niels E. ;
Ostergaard, Christian ;
Kjaer, Jesper ;
Grarup, Jesper ;
Lundgren, Jens D. .
CRITICAL CARE MEDICINE, 2011, 39 (09) :2048-2058
[2]
Biomarkers in the Critically Ill Patient: C-reactive Protein [J].
Vincent, Jean-Louis ;
Donadello, Katia ;
Schmit, Xavier .
CRITICAL CARE CLINICS, 2011, 27 (02) :241-+
[3]
Early diagnosis of sepsis using serum biomarkers [J].
Chan, Terence ;
Gu, Frank .
EXPERT REVIEW OF MOLECULAR DIAGNOSTICS, 2011, 11 (05) :487-496
[4]
Use of procalcitonin to reduce patients' exposure to antibiotics in intensive care units (PRORATA trial): a multicentre randomised controlled trial [J].
Bouadma, Lila ;
Luyt, Charles-Edouard ;
Tubach, Florence ;
Cracco, Christophe ;
Alvarez, Antonio ;
Schwebel, Carole ;
Schortgen, Frederique ;
Lasocki, Sigismond ;
Veber, Benoit ;
Dehoux, Monique ;
Bernard, Maguy ;
Pasquet, Blandine ;
Regnier, Bernard ;
Brun-Buisson, Christian ;
Chastre, Jean ;
Wolff, Michel .
LANCET, 2010, 375 (9713) :463-474
[5]
The diagnostic role of Procalcitonin and other biomarkers in discriminating infectious from non-infectious fever [J].
Limper, M. ;
de Kruif, M. D. ;
Duits, A. J. ;
Brandjes, D. P. M. ;
van Gorp, E. C. M. .
JOURNAL OF INFECTION, 2010, 60 (06) :409-416
[6]
Biomarkers of sepsis [J].
Marshall, John C. ;
Reinhart, Konrad .
CRITICAL CARE MEDICINE, 2009, 37 (07) :2290-2298
[7]
Soluble TREM-1 is not suitable for distinguishing between systemic inflammatory response syndrome and sepsis survivors and nonsurvivors in the early stage of acute inflammation [J].
Bopp, Christian ;
Hofer, Stefan ;
Bouchon, Axel ;
Zimmermann, Johannes B. ;
Martin, Eike ;
Weigand, Markus A. .
EUROPEAN JOURNAL OF ANAESTHESIOLOGY, 2009, 26 (06) :504-507
[8]
Diagnostic Implications of Soluble Triggering Receptor Expressed on Myeloid Cells-1 in BAL Fluid of Patients With Pulmonary Infiltrates in the ICU [J].
Anand, Nitin J. ;
Zuick, Scott ;
Klesney-Tait, Julia ;
Kollef, Marin H. .
CHEST, 2009, 135 (03) :641-647
[9]
Procalcitonin assay in systemic inflammation; infection; and sepsis: Clinical utility and limitations.[J].Kenneth L. Becker;Richard Snider;Eric S. Nylen.Critical Care Medicine.2008, 3
[10]
The time course of blood C-reactive protein concentrations in relation to the response to initial antimicrobial therapy in patients with sepsis [J].
Schmit, X. ;
Vincent, J. L. .
INFECTION, 2008, 36 (03) :213-219