钠摄入量对心力衰竭大鼠心脏肾素-血管紧张素系统与心钠素的影响

被引：12

作者：

张素珍

徐永

万瑜

杨钢

机构：

[1] 广东医学院病理生理学教研室

[2] 广东医学院生理学教研室

[3] 广东医学院武汉大学医学院生理学教研室

[4] 广东医学院武汉大学医学院生理学教研室广东湛江

[5] 广东湛江

[6] 湖北武汉

来源：

第四军医大学学报 | 2002年 / 12期

关键词：

心力衰竭,充血性; 肾素-血管紧张素系统; 心钠素; 钠;

D O I：

暂无

中图分类号：

R541.6 [血液循环衰竭];

学科分类号：

1002 ; 100201 ;

摘要：

目的　观察钠摄入量对心力衰竭大鼠心脏局部肾素-血管紧张素系统与心钠素的影响 .方法　经动 -静脉分流术造成大鼠充血性心衰模型 ,分为心衰组、心衰限钠组、心衰补钠组 ,假手术大鼠为对照组 ,用放射免疫分析法和原位杂交技术分别测定各组血浆和心肌血管紧张素、心钠素含量及心肌血管紧张素原 m RNA表达水平 (吸光度 A值 ) ,同时检测心功能 .结果　心衰限钠组心房和心室血管紧张素含量(2 0 .1± 4 .5 )和 (2 7.3± 5 .9) ng· g- 1、血管紧张素原 m RNA表达 (6 .4± 1.2 )和 (12 .6± 2 .3)显著高于心衰组 (17.5± 3.6 )和 (2 0 .1± 3.7) ng· g- 1 ,(6 .2± 1.9)和 (8.6± 1.7) (P<0 .0 5 ,P<0 .0 1) ,心室心钠素 (42 3± 6 8) ng· g- 1 也显著高于心衰组 (337± 86 ) ng· g- 1 (P<0 .0 5 ) ,心房心钠素 (6 7± 19)μg· g- 1显著低于心衰组 (85± 15 ) μg· g- 1 (P<0 .0 5 ) ;心衰补钠组心房和心室血管紧张素原 m RNA表达水平、心室血管紧张素和心钠素与心衰组无显著差别 ,心房血管紧张素与对照组无显著差别 ,心房心钠素 (10 1± 17) μg· g- 1 显著高于心衰组 (P<0 .0 1) .结论　心衰时不同钠摄入量可通过改变心脏局部肾素 -血管紧张素系统与心钠素的平衡状态在心衰发展进程中发挥作用

引用

页码：1090 / 1093

页数：4

共 10 条

[1]

Systemic and renal effects of atrial natriuretic peptide in patients with heart failure treated with angiotensin-converting enzyme inhibitor or in acute saline solution loading. Tomiyama H,Watanabe G,Abe M,Okazaki R,Yoshida H,Doba N. American Heart Journal . 2000

[2]

Effects of captopril on enzymatology of cultured anoxic-reperfused ventricular myocardial cells. Yu SQ,Ren YA,Wang G,Liu WY,Tang CW. Journal of the Fourth Military Medical University . 2000

[3]

Endogenous natriuretic peptides participate in renal and humoral actions of acute vasopeptidase inhibition in experimental mild heart failure. Chen HH,Lainchbury JG,Matsuda Y,Harty GJ,Burmett GC Jr. Journal of Hypertension . 2000

[4]

Angiotensin Ⅱ, adbesion, and cardiac fibrosis. Schnee JM,Haueh WA. Cardiovascular Research . 2000

[5]

Effects of sodium restricted or supplemented on atrial natriuretic polypeptide and cardiac function of rats with congestive heart failure. Zhang SZ,Wan Y,Yang G,Xu Y,Hu JM,Xu FL. Zhongguo Bingli Shengli Zazhi ( Chin J Pathophysiol ) . 2001

[6]

The role of angiotensin receptor blockers in the management of chronic heart filure. Janali AH,Tang WH,Khot UN,Fowler MB. Archives of Internal Medicine . 2001

[7]

Changes of myocardial renin activity, the content of angiotensin Ⅱ and norepinephrine in the brief postischemic reperfused myocardium in the rabbit. Jia QH,Jia GL,Chen SL,Li XY,Chen M,Cao YX. Journal of the Fourth Military Medical University . 1996

[8]

Inhibitory effect of matriuretic peptides on proliferation of cardiac myocytes in neonatal rats. Dong MQ,Zhu MZ,Yu J,Feng HS,Shi PT. Journal of the Fourth Military Medical University . 2000

[9]

Effects of human atrial natriuretic peptide on endogenous atrial natriuretic peptide and endothelin secretion in patients with pregnancy induced hypertension. Yang Y,Yang MG,Luo YN,Zhang XL,Tong J,Jiang F. Journal of the Fourth Military Medical University . 1999

[10]

Angiotensin acts on the wound healing of obdominal operation. Zhao ZQ,Zhu WX. Journal of the Fourth Military Medical University . 2000

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