尤瑞克林治疗大面积脑梗死的临床分析及文献回顾

被引:3
作者
夏海平 [1 ,2 ]
任乃勇 [1 ]
钱进军 [1 ]
赵康仁 [1 ]
刘娜 [3 ]
于明 [2 ,4 ]
机构
[1] 江苏大学附属第四人民医院神经科
[2] 江苏大学临床医学院神经病学教研室
[3] 江苏省镇江市第一人民医院神经科
[4] 江苏大学附属医院神经科
关键词
尤瑞克林; 大面积脑梗死; 疗效;
D O I
暂无
中图分类号
R743.3 [急性脑血管疾病(中风)];
学科分类号
摘要
目的探讨尤瑞克林治疗大面积脑梗死的临床疗效。方法将大面积脑梗死患者60例随机分为对照组和治疗组,对照组(30例)接受常规治疗,治疗组(30例)在常规治疗的基础上给予尤瑞克林治疗。观察比较治疗前后神经功能缺损(NIHSS)、Barthel指数及日常生活能力量表(ADL)评分,评估患者治疗效果。结果治疗10、20d后各项评分变化差异有统计学意义(P<0.01);治疗组疗效明显优于对照组(P<0.01或P<0.05)。结论尤瑞克林注射液可以明显改善大面积脑梗死患者的意识及神经功能缺损,降低病死率,有助于改善预后,提高患者的存活率及生存质量。
引用
收藏
页码:2963 / 2964
页数:2
相关论文
共 10 条
  • [1] Kallikrein inhibitors limit kinin B(2) antagonist-induced progression of oedematous to haemorrhagic pancreatitis in rats. Griesbacher T,Rainer I,Tiran B,Peskar B A. British Journal of Pharmacology . 2008
  • [2] Skin barrier homeostasis in atopic dermatitis: feedback regulation of kallikrein activity. Tanaka Reiko J,Ono Masahiro,Harrington Heather A. PloS one . 2011
  • [3] Human urinary kallidinogenase suppresses cerebral inflammation in experimental stroke and downregulates nuclear factor-kappa B. Zhi-bin Chen,Dan-qing Huang,Feng-nan Niu. Journal of Cerebral Blood Flow and Metabolism . 2010
  • [4] Tissue kal-likrein alleviates glutamate-induced neuro-toxicity by activating ERK1. Liu L,Zhang R,Liu K,et al. Journal of Neuroscience Research . 2009
  • [5] Classification of Subtype of Acute Ischemic Stroke: Definitions for Use in a Multicenter Clinical Trial[J] . Harold P. Adams,Birgitte H. Bendixen,L. Jaap Kappelle,José Biller,Betsy B. Love,David Lee Gordon,E. Eugene Marsh. &nbspStroke . 1993 (1)
  • [6] Kallikrein Gene Transfer Protects Against Ischemic Stroke by Promoting Glial Cell Migration and Inhibiting Apoptosis[J] . Chun-Fang Xia,Hang Yin,Cesar V. Borlongan,Lee Chao,Julie Chao. &nbspHypertension: Journal of the American Heart Association . 2004 (2, P)
  • [7] Human Tissue Kallikrein Promoted Activation of the Ipsilesional Sensorimotor Cortex after Acute Cerebral Infarction
    Wang, Yi-Dong
    Lu, Rui-Yan
    Huang, Xiao-Xiong
    Yuan, Fang
    Hu, Tao
    Peng, Ying
    Huang, Sui-Qiao
    [J]. EUROPEAN NEUROLOGY, 2011, 65 (04) : 208 - 214
  • [8] 神经病学临床评定量表[M]. 中国友谊出版公司 , 邓亚仙[等]著, 2005
  • [9] 脑卒中患者临床神经功能缺损程度评分标准
    盛莉
    [J]. 中国乡村医药, 1995, (01) : 45 - 45
  • [10] Ecallantide for the treatment of acute attacks in hereditary angioedema. Cicardi Marco,Levy Robyn J,McNeil Donald L,Li H Henry,Sheffer Albert L,Campion Marilyn,Horn Patrick T,Pullman William E. The New England Quarterly . 2010