颅脑创伤后的血清皮质醇变化及对机体的影响

被引：15

作者：

徐鹏

张国斌

刘睽

只达石

机构：

[1] 天津市环湖医院神经外科

来源：

国际神经病学神经外科学杂志 | 2008年 / 05期

关键词：

颅脑创伤; 血清皮质醇; 下丘脑-垂体-肾上腺轴;

D O I：

10.16636/j.cnki.jinn.2008.05.006

中图分类号：

R651.1 [颅脑];

学科分类号：

1002 ; 100210 ;

摘要：

颅脑创伤后的血清皮质醇变化对于疾病的发展与转归起重要作用,其变化原因主要包括应激反应、下丘脑-垂体损伤和免疫反应等,其适当的增高可以增强机体对创伤损害的抵抗能力,长期过度的血清高浓度或者低浓度皮质醇水平则可能导致体内代谢紊乱,出现一系列并发症,主要包括神经系统损害、脑心综合征、应激性溃疡、免疫系统损害、凝血功能障碍、糖代谢紊乱以及肾上腺皮质功能减退症等,有必要动态观察颅脑创伤后血清皮质醇的变化,通过各种方法避免血清皮质醇过高或者过低对机体的损害。

引用

页码：420 / 423

页数：4

共 12 条

[1] 突发情感应激所致心肌功能丧失的神经体液特征 [J].

Wittstein I.S. ;

Thiemann D.R. ;

Lima J.A.C. ;

赵和平 .

世界核心医学期刊文摘(心脏病学分册), 2005, (07) :23-24

[2]

Diabetes Insipidus, Secondary Hypoadrenalism and Hypothyroidism after Traumatic Brain Injury: Clinical Implications[J] . S. Tsagarakis,M. Tzanela,I. Dimopoulou.Pituitary . 2006 (3)

[3]

Acute secondary adrenal insufficiency after traumatic brain injury: A prospective study[J] . Pejman Cohan,Christina Wang,David L. McArthur,Shon W. Cook,Joshua R. Dusick,Bob Armin,Ronald Swerdloff,Paul Vespa,Jan Paul Muizelaar,Henry Gill Cryer,Peter D. Christenson,Daniel F. Kelly.Critical Care Medicine . 2005 (10)

[4] AVP- and OT-neurophysins response to apomorphine and clonidine in major depression [J].

Scantamburlo, G ;

Hansenne, M ;

Fuchs, S ;

Pitchot, W ;

Pinto, E ;

Reggers, J ;

Ansseau, M ;

Legros, JJ .

PSYCHONEUROENDOCRINOLOGY, 2005, 30 (09) :839-845

[5] Effect of cortisol infusion patterns and castration on metabolic and immunological indices of stress response in cattle [J].

Ting, STL ;

Earley, B ;

Crowe, MA .

DOMESTIC ANIMAL ENDOCRINOLOGY, 2004, 26 (04) :329-349

[6] Surviving Sepsis Campaign guidelines for management of severe sepsis and septic shock [J].

Dellinger, RP ;

Carlet, JM ;

Masur, H ;

Gerlach, H ;

Calandra, T ;

Cohen, J ;

Gea-Banacloche, J ;

Keh, D ;

Marshall, JC ;

Parker, MM ;

Ramsay, G ;

Zimmerman, JL ;

Vincent, JL ;

Levy, MM .

CRITICAL CARE MEDICINE, 2004, 32 (03) :858-873

[7]

The Neuroendocrinology of Posttraumatic Stress Disorder: New Directions[J] . Ann M. Rasmusson,Meena Vythilingam,Charles A. Morgan.CNS Spectrums . 2003 (9)

[8]

Stable individual differences in physiological response to stressors: implications for stress-elicited changes in immune related health[J] . S. Cohen,N. Hamrick.Brain Behavior and Immunity . 2003 (6)

[9]

Cortisol Response to Corticotropin Stimulation in Trauma Patients: Influence of Hemorrhagic Shock[J] . Sophie Hoen,Karim Asehnoune,Sylvie Brailly-Tabard,Jean-Xavier Mazoit,Dan Benhamou,Pierre Moine,Alain R. Edouard.Anesthesiology . 2002 (4)

[10] Clonidine pretreatment inhibits stress-induced gastric ulcer in rats [J].

Yelken, B ;

Dorman, T ;

Erkasap, S ;

Dundar, E ;

Tanriverdi, B .

ANESTHESIA AND ANALGESIA, 1999, 89 (01) :159-162

← 1 2 →