肾小球滤过屏障及nephrin分子

被引:4
作者
张敬京
丁洁
杨霁云
机构
[1] 北京大学第一医院儿科!北京
关键词
肾小球膜; nephrin; 肾疾病; 免疫球蛋白类;
D O I
暂无
中图分类号
R334.1 [];
学科分类号
1001 ;
摘要
新近认识的nephrin分子为肾小球裂孔隔膜上第一个被确定的蛋白成分。nephrin参与肾脏滤过屏障的正常发育并维持其正常功能。已经在芬兰型先天性肾病综合征患者检测到编码nephrin的基因NPHS1的多种突变;此外,NPHS1突变以及nephrin表达异常可能也是其他先天性或获得性肾脏病蛋白尿发生的原因。
引用
收藏
页码:1 / 3
页数:3
相关论文
共 12 条
[1]  
Unraveling the mechanisms of glomerular ultrafil- tration:nephrin, a key component of the slit diaphragm. Tryggvason K. Journal of the American Society of Nephrology . 1999
[2]  
Congenital nephritic syndromein mice lacking CD2 associated protein. Shih NY,Li J,Karpitskii V,et al. Science . 1999
[3]  
Congenital nephriticsyndrome of the Finnish type maps to the long arm of chromosome19. Kestila M,Mannikko M,Holmberg C,et al. The American Journal of Human Genetics . 1994
[4]  
Glomerular expression ofnephrin is decreased in acquired human nephritic syndrome. Fumess PN,Hall LL,Shaw JA. et al. Nephrology Dialysis Transplantation . 1999
[5]  
Structure of thegene for congenital nephrotic syndrome of the Finnish type(NPHS1)and characterization of mutations. Lenkkeri U,Mannikko M,MoCready P,et al. The American Journal of Human Genetics . 1999
[6]  
Cloning and expressionof the rat nephrin homolog. Ahola H,Wang SX,Luimula P,et al. American Journal of Pathology . 1999
[7]  
Fine mapping andhapplotype analysis of the locus for congenital nephritic syndromeon chromosome 19q 13. 1. Mannikko M,Kestaila M,Holmberg C,et al. The American Journal of Human Genetics . 1995
[8]  
Nephrin isspecifically located at the slit diaphragm of glomerular podocytes. Ruotsalainen V,Ljungberg P,Wartiovaara J,et al. Proceedings of the National Academy of Sciences of the United States of America . 1999
[9]  
Developmental expression of the nephritogenjc antigen of monoclonal antibody5- 1 -6. Kawachi H,Abrahamson DR,St John PL,et al. American Journal of Pathology . 1995
[10]  
First components found for new kidney filter. Wickelgren I. Science . 1999