细胞色素P450 CYP2E1酶构型特征及其表达调控机制的研究进展

被引：56

作者：

刘晨晖

乐江

机构：

[1] 武汉大学基础医学院药理学系

来源：

中国药理学与毒理学杂志 | 2010年 / 24卷 / 02期

关键词：

细胞色素P450 CYP2E1; 蛋白质结构,二级; 基因表达调控; 自由基;

D O I：

暂无

中图分类号：

R963 [生化药理学];

学科分类号：

100706 [药理学];

摘要：

细胞色素P450CYP2E1酶参与代谢活化及失活多种前毒物、前致癌物和少数药物。在细胞色素P450超家族中,CYP2E1具有易介导自由基生成引发氧化应激反应的特征。CYP2E1表达水平可能是机体对环境和工业毒物或致癌物敏感程度的重要因素。研究表明,CYP2E1可被多种内、外源性物质所调控,并且CYP2E1的药理和毒理学功能与其以蛋白构型为基础的代谢行为密切相关。本文综述了CYP2E1基因多态性、酶构型特征与其代谢活性间的关系,并分析了其区别于其他细胞色素P450亚型的表达调控机制。

引用

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页码：155 / 160

页数：6

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