整合子结构及在细菌耐药性扩散中的作用

被引:9
作者
张之文
王红宁
机构
[1] 四川农业大学动物预防兽医系生物工程实验室
[2] 四川农业大学动物预防兽医系生物工程实验室 雅安
[3] 雅安
关键词
整合子; 基因簇; 质粒; 耐药;
D O I
10.13461/j.cnki.wna.003860
中图分类号
R96 [药理学];
学科分类号
100602 ; 100706 ;
摘要
整合子具有特异性整合位点 ,能够整合外来的抗性基因簇。一般定位在质粒或转座子上 ,广泛分布在肠道内革兰氏阴性菌中 ,是耐药基因在病原菌间水平传播的重要因子
引用
收藏
页码:150 / 153
页数:4
相关论文
共 14 条
[1]  
Family of Class 1 Integrons Related to In4 from Tn1696. Sally R P,Gavin D,Stokes H W,et al. Antimicrobial Agents and Chemotherapy . 2001
[2]  
Characterization of the 6’-N-aminoglycoside acetyltransferase gene aac(6′)-Il associated with a sulI - type integron. Hannecart-Pokorni E,Depuydt F,Wit L d,et al. Antimicrobial Agents and Chemotherapy . 1997
[3]  
Expression of antibiotic resistance genes in the integrated cassettes of integrons. Collis C M,Hall R M. Antimicrobial Agents and Chemotherapy . 1995
[4]  
A novel integronlike element carrying the metallo-β-lactamase gene blaIMP. Arakawa Y,Murakami M,Suzuki K,et al. Antimicrobial Agents and Chemotherapy . 1995
[5]  
Antibiotic resistance in gram- negative bacteria: the role of gene cassettes and integrons. Hall R M,Collis C M. Drug Resistance Updates . 1998
[6]  
An integron class 1 represent on the plasmid pCG4 from gram - positive bacterium Corynebacterrium glutamicum. Nesvera J,Hochmannova J,Patek M. FEMS Microbiology Letters . 1998
[7]  
Incidence of class 1 and 2 integron in clinical and commensal bacterial from livestock companion animals and exotics. Cathy G,Margie D L,Susan S,et al. Antimicrobial Agents and Chemotherapy . 2001
[8]  
New gene cassettes for trimethoprim resistance, dfr13, and Streptomycin - Spectinomycin resistance, aadA4, inserted on a class 1 integron. Peter V A,Christopher J T,Keith P K,et al. Antimicrobial Agents and Chemotherapy . 2000
[9]  
A new gene , aadA2b encoding an aminoglycosideanylyl transrease AAD(3")( 9), isolated from integron InC in Peseudomonas aerruginosa. Kazama H,Hizu K,Iwasaki M,et al. Micro . 1996
[10]  
Reconstruction of an active integron recombination site after integration of a gene cassette at a secondary site. Segal H,Franeia M V,Lobo J M G,et al. Antimicrobial Agents and Chemotherapy . 1999