腮腺炎病毒的基因分型及当前疫苗的免疫效果

被引：33

作者：

杨文震

陈志慧

机构：

[1] 上海生物制品研究所

来源：

国外医学(预防、诊断、治疗用生物制品分册) | 2005年 / 02期

关键词：

腮腺炎病毒; 基因分型; 疫苗; 有效性; 安全性;

D O I：

暂无

中图分类号：

R392 [医学免疫学];

学科分类号：

100102 ;

摘要：

腮腺炎是由腮腺炎病毒所导致的急性全身性传染病。腮腺炎病毒只有一个血清型,目前基于其SH基因序列的差异可以区分出A～K 11个基因型。一般使用聚合酶链反应(PCR)与逆转录酶(RT) - PCR分子生物学方法来研究病毒的基因。不同疫苗株的免疫效果有区别,1剂接种与2剂接种的效果也在监测中。已初步建立动物模型可供病毒致神经毒性研究。有报道认为病毒基因型之间存在抗原性差异,但病毒各基因型间有交叉保护作用存在,所以目前使用的疫苗都是安全、有效的

引用

页码：49 / 52

页数：4

共 15 条

[1]

Comparison of the neurovirulence of a vaccine and a wild-type mumps virus strain in the developing rat brain. Rubin SA,Pletnikov M,Carbone KM. Journal of Virology . 1998

[2]

Immunity to mumps before and after MMR vaccination at 12 years of age in the first generation offered the two-dose immunization programme. Broliden K,Abreu ER,Arneborn M,et al. Vaccine . 1998

[3]

Identification of a new genotype H wild-type mumps virus strain and its molecular relatedness to other virulent and attenuated strains. Amexis G,Rubin S,Chatterjee N,et al. Journal of Medical Virology . 2003

[4]

Persistence of anti -mumps virus antibodies after as two-dose MMR vaccination.A nineyear follow-up. Davidkin I,Valle M,Julkunen I. Vaccine . 1995

[5]

Mumps virus neutrali zing antibodies do not protect against reinfection with a heterologous mumps virus genotype. Nojd J,Tecle T,Samuelsson A,et al. Vaccine . 2001

[6]

Evaluation of a neonatal rat model for prediction of mumps virus neurovirulence in humans. Rubin SA,Pletnikov M,Taffs R,et al. Journal of Virology .

[7]

Immunogenicity of second dose measles-mumps-rubella ( MMR ) vaccine and implication for serosurveillance. Pebody RG,Gay NJ,Hesketh LM,et al. Vaccine . 2002

[8]

Antigenic relationships between six genotypes of the small hydrophobic protein gene of mumps virus. Orvell C,Tecle T,Johansson B,et al. Journal of General Virology . 2002

[9]

Outbreak of mumps in a vaccinated child population: a question of vaccine failure. Vandermeulen C,Roelants M,Vermoere M,et al. Vaccine . 2004

[10]

WHO position paper. Mumps virus vaccines. Wkly Epidem Rec . 2001

← 1 2 →