实验性大鼠局灶性脑缺血再灌注后VEGF与TGF-β1的表达及意义

被引：5

作者：

田琳

赵瑞波

吴鹤

吴旖琦

机构：

[1] 哈尔滨医科大学病理学教研室

[2] 哈尔滨医科大学病理学教研室黑龙江哈尔滨

[3] 黑龙江哈尔滨

来源：

哈尔滨医科大学学报 | 2005年 / 01期

关键词：

脑缺血; 血管内皮生长因子; 转化生长因子; 免疫组化;

D O I：

暂无

中图分类号：

R743 [脑血管疾病];

学科分类号：

1002 ;

摘要：

目的　研究大鼠局灶性脑缺血后血管内皮生长因子 (VEGF)、转化生长因子 (TGF β1)在缺血再灌注不同时程和不同部位的表达及意义。方法　采用线栓法制作大鼠局灶性大脑中动脉闭塞模型 ,将动物随机分为正常对照组、假手术组、再灌注 12h、2 4h、3d、7d组。采用免疫组化方法观察大鼠缺血再灌注不同时程VEGF、TGF β1的表达情况。结果　缺血 6h再灌注 12hVEGF、TGF β1即有阳性表达 ,再灌注 2 4hVEGF、TGF β1表达明显增多 ,持续至 3d ,以后表达减少 ,但 7d仍有阳性表达。阳性表达的细胞主要是神经胶质细胞、神经元和血管内皮细胞。各时间段二者的阳性表达主要集中在梗死灶周围区。结论　VEGF、TGF β1共同参与缺血脑损伤的病理发展及修复过程

引用

页码：35 / 37+40 +40

页数：4

共 8 条

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