药物肝损伤的潜在生物标志物循环miR-122的研究进展

被引：15

作者：

王雁

汤纳平

马璟

机构：

[1] 中国医药工业研究总院国家上海新药安全评价研究中心

来源：

中国药理学与毒理学杂志 | 2013年 / 27卷 / 01期

关键词：

微RNAs; miR-122; 生物标志物; 肝; 毒性作用;

D O I：

暂无

中图分类号：

R595.3 [药源性疾病];

学科分类号：

100201 [内科学];

摘要：

药物诱导的肝损伤是药物研发失败或退市的主要原因之一,而传统的肝损伤评价指标因为种种缺陷如缺乏特异性或灵敏性而不能为药物的肝毒性评价提供早期、及时和可靠的信号。循环微RNA-122(miR-122)因其在肝脏特异性表达、以及其高度的稳定性和灵敏性成为目前肝毒性评价指标的研究热点。本综述主要从特异性、稳定性和灵敏性3方面系统地阐述循环miR-122成为肝毒性生物标志物的应用潜力,并对下一步的研究工作进行探讨。

引用

页码：110 / 113

页数：4

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