骨性关节炎损伤因子研究进展

被引:24
作者
鲍隽君
刘永刚
苏佳灿
机构
[1] 第二军医大学附属长海医院骨科
关键词
骨性关节炎; IL; OA; 细胞因子; TNF; Ⅱ型胶原; 基质金属蛋白酶; MMPs; 基质溶解素; 软骨基质; 关节软骨; 损伤因子;
D O I
暂无
中图分类号
R684 [关节疾病及损伤];
学科分类号
摘要
<正>骨性关节炎(osteoarthritis,OA)是中老年人最常见的骨关节病,多累及膝、髋、腰椎等负重关节,其病理特征是关节软骨的原发性或继发性的破坏,并在关节边缘形成代偿性骨赘。近年来研究发现,OA是在力学与生物学的共同
引用
收藏
页码:3055 / 3057
页数:3
相关论文
共 13 条
[1]   骨性关节炎膝关节液及血清中MMP-9、TNF-α水平检测及意义 [J].
蒋太军 .
西南国防医药, 2009, 19 (04) :380-382
[2]   白血病抑制因子在骨性关节炎组织的表达及临床研究 [J].
蒋煜文 ;
舒钧 ;
胡侦明 ;
劳汉昌 .
浙江中医药大学学报, 2007, (04) :431-433
[3]   肿瘤坏死因子受体p55和p75在骨关节炎软骨细胞的表达及意义 [J].
周京国 ;
郭晓兰 ;
袁国华 ;
魏锦 ;
唐中 ;
杨明辉 .
中华风湿病学杂志, 2007, (01) :12-15
[4]  
Role of a LIF antagonist in LIF and OSM induced MMP-1, MMP-3, and TIMP-1 expression by primary articular chondrocytes[J] . Aradhana Upadhyay,Gaurav Sharma,Satu Kivivuori,Warren S. Raye,Ebrahim Zabihi,Graeme J. Carroll,Jalal A. Jazayeri.Cytokine . 2009 (3)
[5]   Effects of culture conditions and exposure to catabolic stimulators (IL-1 and retinoic acid) on the expression of matrix metalloproteinases (MMPs) and disintegrin metalloproteinases (ADAMs) by articular cartilage chondrocytes [J].
Flannery, CR ;
Little, CB ;
Caterson, B ;
Hughes, CE .
MATRIX BIOLOGY, 1999, 18 (03) :225-237
[6]   Retinoic acid blocks pro-inflammatory cytokine-induced matrix metalloproteinase production by down-regulating JNK-AP-1 signaling in human chondrocytes [J].
Ho, LJ ;
Lin, LC ;
Hung, LF ;
Wang, SJ ;
Lee, CH ;
Chang, DM ;
Lai, JH ;
Tai, TY .
BIOCHEMICAL PHARMACOLOGY, 2005, 70 (02) :200-208
[7]   Elevated IL-6 levels in the synovial fluid of osteoarthritis patients stem from plasma cells [J].
Doss, F. ;
Menard, J. ;
Hauschild, M. ;
Kreutzer, H-J ;
Mittlmeier, T. ;
Mueller-Steinhardt, M. ;
Mueller, B. .
SCANDINAVIAN JOURNAL OF RHEUMATOLOGY, 2007, 36 (02) :136-139
[8]  
Expression of interleukin‐6 in osteoarthritic chondrocytes and effects of fluid‐induced shear on this expression in normal human chondrocytes in vitro[J] . M. Mohtai,M. K. Gupta,B. Donlon,B. Ellison,J. Cooke,G. Gibbons,D. J. Schurman,R. Lane Smith.J. Orthop. Res. . 2005 (1)
[9]  
Inflammatory Cytokines in Relation to Adrenal Response Following Total Hip Replacement[J] . G. L.Bjornsson,L.Thorsteinsson,K. O.Gudmundsson,H.Jonsson,S.Gudmundsson,B.Gudbjornsson.Scandinavian Journal of Immunology . 2006 (1)
[10]  
Matrix Metalloproteinases And Aggrecanase: Their Role in Disorders of the Human Intervertebral Disc[J] . Sally Roberts,Bruce Caterson,Janis Menage,E. Helena Evans,David C. Jaffray,Stephen M. Eisenstein.Spine . 2000 (23)