青蒿琥酯对大鼠孕酮、雌二醇和蜕膜组织的影响

被引：20

作者：

娄小娥

周慧君

机构：

[1] 浙江大学药学院!浙江杭州

来源：

药学学报 | 2001年 / 04期

关键词：

青蒿琥酯; 孕酮; 雌二醇; 蜕膜; 终止妊娠;

D O I：

10.16438/j.0513-4870.2001.04.004

中图分类号：

R965 [实验药理学];

学科分类号：

摘要：

目的　研究青蒿琥酯对妊娠大鼠血清孕酮和雌二醇含量及蜕膜组织的影响 ,以探讨其终止妊娠机理。方法　采用放射免疫分析法 (RIA)、HE染色和人蜕膜细胞体外培养等方法。结果　青蒿琥酯 40mg·kg-1·5d可使妊娠大鼠血清孕酮水平显著下降 (P <0 0 5 ) ;雌二醇有下降趋势 ,肿瘤坏死因子水平则有上升趋势 ;整体水平能损伤蜕膜组织乃至胎盘 ;对体外培养的人蜕膜细胞有直接杀伤作用 ,其LC50 为 ( 2 5± 3)mg·L-1。结论　青蒿琥酯能使血清孕酮含量下降并损伤蜕膜和胎盘而使胚胎坏死、吸收而终止妊娠

引用

页码：254 / 257

页数：4

共 8 条

[1] Studies on the toxicity of qinghaosu and its derivatives. China Cooperative Research Group on Qinghaosu and Its Derivatives as Antimalarials. J Tradit Chin Med (in Chinese) . 1982
[2] Tumor necrosis factor-αstimulates the biosynthesis of matrix metalloproteinases and plasminogen activator in cultured human chorionic cell. So T,Ito T,Mori Y,et al. Biology of Reproduction . 1992
[3] Toxicity to transferred rat embryos after aspirin treatment during preimplantation stage in vivo. Lou YJ,Ding GS,Tu ZH. Acta Pharmacological Sinica . 1996
[4] Synergistic effects on pregnancytermination activity of DL111-IT in combination with mifepristone. Yang BO,Fang RY. Acta Pharmacological Sinica . 1996
[5] Chemical stability of artesunate injection and proposal for its administration by intravenous infusion. Batty KT,Ilett KF,Davis T,et al. Journal of Pharmacokinetics and Pharmacodynamics . 1996
[6] Contragestation effects of dihydroartemisinin and artesunate. Xu JH,Zhang YP. Acta Pharmacological Sinica . 1996
[7] Growth characteristics of human first trimester decidual cells cultured in serum-free medium: Production of prolactin,prostaglandins and fibronectin. Hochner CD,Ron M,Eldor A,et al. Biology of Reproduction . 1984
[8] How Chinese scientists discovered qinghaosu ( artemisinin) and developed its derivatives?What are the future perspectives. Li Y,Wu YL. Medecine Tropicale . 1998

← 1 →