树突状细胞与自身免疫病研究进展

被引：4

作者：

袁欣然

王丹丹

孙凌云

机构：

[1] 南京大学医学院附属鼓楼医院风湿免疫科

来源：

中华风湿病学杂志 | 2017年 / 21卷 / 11期

关键词：

D O I：

暂无

中图分类号：

R593.2 [自身免疫性疾病、结缔组织疾病];

学科分类号：

100201 [内科学];

摘要：

<正>树突状细胞（dendritic cells,DC）是特殊的"哨兵"细胞,其连接固有免疫和获得性免疫。DC通过模式识别受体来识别病原体,并迁移至淋巴器官的T细胞区,将抗原递呈给特异性T细胞。自身免疫病主要是由于自身耐受的平衡被破坏而引起,而DC与自身免疫病的发生关系密切[1]。在遗传和环境因素的影响下,固有免疫和获得性免疫功能紊乱,机体对自身抗原决定簇耐受能力减退或丧失,从而自身反应性淋巴细

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