脑梗死患者氧化型低密度脂蛋白与颈动脉粥样硬化的相关性研究

被引:7
作者
王振华 [1 ,2 ]
钟池 [1 ]
赵斌 [1 ]
王洪刚 [3 ]
邢国平 [1 ]
机构
[1] 潍坊医学院附属潍坊市人民医院神经内科
[2] 潍坊市中医院神经内科
[3] 潍坊市人民医院检验科
关键词
脑梗死; 颈总动脉内中膜厚度; 氧化型低密度脂蛋白;
D O I
暂无
中图分类号
R743.3 [急性脑血管疾病(中风)];
学科分类号
摘要
目的研究脑梗死患者氧化型低密度脂蛋白(oxidized low-density lipoprotein,oxLDL)与颈动脉粥样硬化之间的相关性。方法入选脑梗死患者68例,根据彩色多普勒检查颈总动脉平均内中膜厚度,将其分为内膜正常组30例和内膜增厚组38例。并取33例年龄相当的健康受试者作为对照组。采用酶联免疫吸附法测定血清oxLDL的含量。比较不同组别间oxLDL水平的差异以及oxLDL与颈动脉粥样硬化的关系。结果脑梗死组患者的oxLDL水平明显高于健康对照组(P<0.01)。脑梗死患者中颈总动脉内中膜厚度(intima-media thickness,IMT)增厚组的oxLDL水平明显高于IMT正常组(P<0.01);Spearman等级相关分析提示,oxLDL的水平与颈动脉粥样硬化呈正相关(r=0.572,P<0.01);Logistic回归分析提示,oxLDL可认为是脑梗死患者颈动脉粥样硬化的可能独立危险因素(OR=3.896,P=0.002)。结论脑梗死患者的血清oxLDL水平显著升高,并与颈动脉粥样硬化密切相关。
引用
收藏
页码:134 / 138
页数:5
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