胃癌组织中PTEN和VEGF表达的相关性研究

被引：2

作者：

郭建红

宋宏伟

李士瑛

机构：

[1] 山西医科大学病理学教研室

[2] 山西省肿瘤研究所

来源：

山西医科大学学报 | 2003年 / 06期

关键词：

胃肿瘤; 内皮生长因子; 内皮,血管; 免疫组织化学; 基因,PTEN;

D O I：

暂无

中图分类号：

R735.2 [胃肿瘤];

学科分类号：

摘要：

目的　通过对PTEN和血管内皮生长因子 (vascularendothelialgrowthfactor ,VEGF)在胃癌中表达的研究 ,结合临床病理特征 ,探讨PTEN和VEGF的相关性。方法　应用免疫组织化学S -P法检测 6 8例胃癌组织及 2 0例正常胃黏膜中PTEN和VEGF的表达。结果　胃癌组织中PTEN蛋白表达率为 4 7.1% (33/ 6 8) ,显著低于正常胃黏膜的表达 10 0 % (2 0 /2 0 ) (P <0 .0 1) ,与组织分化程度呈正相关 (P <0 .0 1) ,与淋巴结转移呈负相关 (P <0 .0 5 )。VEGF在胃癌中的表达率为 75 .0 %(5 1/ 6 8) ,显著高于正常胃黏膜的表达 10 .0 % (2 / 2 0 ) (P <0 .0 1) ,与癌组织浸润深度呈正相关 (P <0 .0 1) ,与淋巴结转移也呈正相关 (P <0 .0 5 ) ,与组织分化程度无关。PTEN在胃癌中的表达与VEGF呈负相关 (P <0 .0 1)。结论　PTEN失活或蛋白表达降低与胃癌的组织分化程度及淋巴结转移密切相关 ,且与VEGF呈显著负相关。联合检测PTEN、VEGF有助于提高胃癌侵袭转移能力的评估 ,对胃癌的预后判断具有重要的临床意义。

引用

页码：481 / 484

页数：4

共 14 条

[1]

Adenovirus-mediated gene transfer of MMAC1/PTEN to glioblastoma cells inhibits S phase entry by the recruitment of p 27 kipl into cyclin E/CDK2 complexes. Cheney IW,Neuteboom ST,Vaillancourt MT,et al. Cancer Research . 1999

[2]

Freguent loss of PTEN expression is liked to elevated phosporylated AKT levels, but not associated with p27 and cyclin D expression, in primary epithelial ovarian carcinomas. Kurose K,Zhou XP,Araki T,et al. American Journal of Pathology . 2001

[3]

Correlation between express of vascular endothelial growth factor and tumor vascular and patient outcome in human gastric carcinoma. Tanigawa N,Amaya H,Matsumura M,et al. Journal of Clinical Oncology . 1997

[4]

Angiogenic-induced enhancement of collateral blood flow to ischemic myocardium by vascular endothelial growth factor in dogs. Banai S,Jaklitsh MT,Shou M,et al. Circulation . 1994

[5]

Prognostic value of vascular en-dothelial growth factor expression in gastric carcinoma. Meada K,,Chung YS,Ogawa Y,et al. Cancer Research . 1996

[6]

Promoter methylation and silencing of PTEN in gastric carcinoma. Kang YH,Lee Hs,Kim WH. Laboratory Investigation . 2002

[7]

Suppression of tumorigenicity and metastasis in B16F10 cells by PTEN/MMAC1/TEP1 Gene. Hwang PH,Yi HK,Kim DS,et al. Cancer Letters . 2001

[8]

HEER2 (neu) signaling increases the rate of hupoxia-inducible factor 1 alpha (HIF1 alpha) synthesis: novel mechanism for HIF-mediated vascular endothelial growth factor expression. Laughner E,Taghavi P,Chiles K,et al. Molecular and Cellular Biology . 2001

[9]

Modulation of hypoxiainducible factor 1 alpha expression by the epidermal growth factor/phosphatidylinositol 3-kinase/PTEN/AKT/ FRAP pathway in human prostate cancer cells: implications for tumor angiogenesis and therapeutics. Zhong H,Chiles K,Felolser D,et al. Cancer Research . 2000

[10]

Loss of PTEN facilitates HIF-1-mediated gene expression. Zundel W,Schindler C,Haas-Kogan D,et al. Genes and Development . 2000

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