IL-35在免疫相关疾病中的研究进展

被引：4

作者：

王志会

机构：

[1] 三峡大学第二临床学院检验科

来源：

华中科技大学学报(医学版) | 2015年 / 44卷 / 02期

关键词：

白细胞介素-35; 自身免疫疾病; 肿瘤;

D O I：

暂无

中图分类号：

R593 [免疫性疾病];

学科分类号：

100201 [内科学];

摘要：

<正>白细胞介素-35(IL-35)是白细胞介素-12(IL-12)家族的新成员,由Collison等[1]在2007年最先发现并确认。IL-12家族共有4个成员,分别为:IL-12、IL-23、IL-27、IL-35。这4种细胞因子均为异质二聚体,每1个异质二聚体细胞因子均由1个折叠螺旋束样细胞因子(four helix bundle cytokines)亚单位(IL-12p35、IL-23p19、IL-27p28、IL-35p35)和1个可溶型细胞因子受体样亚单位(p40和EBl3)组成(图1)[2]。1 IL-35及其家族成员受体IL-12受体为IL-12Rβ1/IL-12Rβ2二聚体,2个

引用

页码：239 / 242

页数：4

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