脑梗死急性期他汀用药剂量与康复预后相关性的回顾研究

被引：7

作者：

谈晓牧 ^{[1
]}

曾艳芳 ^{[1
]}

刘建国 ^{[2
]}

刘怀翔 ^{[3
]}

耿晓坤 ^{[1
]}

孟繁花 ^{[1
]}

张伟东 ^{[1
]}

魏建朝 ^{[1
]}

杜会山 ^{[1
]}

机构：

[1] 首都医科大学附属北京潞河医院神经内科

[2] 海军总医院神经内科

[3] 天津医科大学第二附属医院神经内科

来源：

北京医学 | 2016年 / 38卷 / 05期

关键词：

脑梗死; 他汀; 康复; 预后;

D O I：

10.15932/j.0253-9713.2016.5.012

中图分类号：

R743.3 [急性脑血管疾病（中风）];

学科分类号：

摘要：

目的探讨脑梗死急性期口服不同剂量阿托伐他汀对患者临床康复预后的影响。方法回顾性分析356例脑梗死患者的临床资料,根据患者住院期间口服阿托伐他汀剂量进行分组,20 mg组153例,40 mg组137例,60 mg组19例,80 mg组47例,比较分析各组患者的人口学资料、脑血管病危险因素分布及主要危险因素控制用药种类分布和NIHSS评分。结果各组患者人口学资料、脑血管病危险因素分布和主要危险因素控制用药种类分布差异无统计学意义。组间NIHSS评分有效率差异有统计学意义（χ2=8.041,P=0.045）,应用卡方分割法进一步检验,显示20～40 mg组与60～80 mg组NIHSS评分有效率差异具有显著性（有效率分别为32.76%、50.00%,χ2=6.941,P=0.008）。Logistic回归分析显示阿托伐他汀剂量为急性脑梗死临床康复预后的独立影响因素,OR值为1.382,95%可信区间1.111～1.719,P=0.004。结论脑梗死急性期应用高剂量阿托伐他汀对于改善患者康复预后具有更好的促进作用。

引用

页码：424 / 428

页数：5

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