精神分裂症致病基因的研究进展

被引:3
作者
李洪
刘建勋
机构
[1] 天津市安定医院
关键词
精神分裂症; 染色体; 多态性; 连锁分析; 早发性痴呆; 致病基因; 高发家系;
D O I
暂无
中图分类号
R749.3 [精神分裂症];
学科分类号
100205 ;
摘要
<正> 迄今许多单基因遗传病已成功地定位在人类基因组上,其中部分已完成定位克隆,但对精神分裂症这种具有复杂遗传模式疾病的研究遇到了很大困难。以往对家系、双生子及寄养子流行病学的大量研究提示精神分裂症易感性的65%~85%取决于基因。这些遗传基因应该表现在DNA序列的表达及调控上。由于精神分裂症属于非经典孟德尔遗传,现认为可能是由几个中度效应基因遗传或多个轻度微效基因遗传。现就近年来该领域的研究进展总结如下。
引用
收藏
页码:231 / 232
页数:2
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