缺血性中风急性期证候特征与生物学指标的关系

被引：16

作者：

刘璐

高颖

马斌

机构：

[1] 北京中医药大学东直门医院神经内科

来源：

中华中医药杂志 | 2011年 / 26卷 / 05期

关键词：

缺血性中风; 证候要素; 生物学指标; 广义规则归纳; 分类回归树;

D O I：

暂无

中图分类号：

R277.7 [中医神经病学与精神病学];

学科分类号：

1005 ;

摘要：

目的:探讨缺血性中风急性期证候与相关生物学指标的关系,从微观辨证的角度阐明证候与疾病的关系。方法:用ELISA法测定175例急性期缺血性中风病患者起病后72h内、第7、14d热休克蛋白70(HSP70)、细胞间黏附分子1(ICAM-1)及金属基质蛋白酶9(MMP9)表达水平的变化,并动态采集四诊信息判断其证候要素。应用广义规则归纳(GRI)和分类回归树(C&RT)对其数据进行挖掘分析。结果:应用GRI发现血瘀证在3个时间点均与缺血性中风急性期相关生物学指标存在密切关联。应用C&RT发现HSP70表达水平是影响气虚证最重要的因素。结论:研究提示HSP70、ICAM-1、MMP9可能是缺血性中风急性期血瘀证的微观指标,提示HSP70可能为气虚证的微观指标。

引用

页码：1086 / 1090

页数：5

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