抗苗勒管激素与多囊卵巢不孕患者有无排卵的相关关系

被引：8

作者：

李键

乔杰

赵淑云

王静

严杰

李蓉

机构：

[1] 北京大学第三医院

来源：

中国妇产科临床杂志 | 2008年 / 05期

关键词：

多囊卵巢; 抗苗勒管激素; 卵泡生长停滞;

D O I：

暂无

中图分类号：

R711.75 [卵巢疾病]; R711.6 [不育症];

学科分类号：

100211 [妇产科学];

摘要：

目的研究抗苗勒管激素(AMH)与多囊卵巢(PCO)不孕患者有无排卵的关系,探讨AMH在卵巢卵泡生长和发育停滞中的作用。方法采用酶联免疫吸附法(ELISA)检测35例正常卵巢形态的排卵妇女(A组)、29例PCO伴正常排卵妇女(B组)和38例PCO伴排卵障碍妇女(C组)的月经第2d(d2)血清及排卵前卵泡液(FF)的AMH水平。结果B组和C组的月经d2血清AMH水平比较,差异无显著性(5.87ng/ml和7.99ng/ml;P>0.05),但显著高于A组(2.52ng/ml;P<0.01)。月经d2血清AMH与小窦泡卵数呈正相关(r=0.53;P<0.05)。B组和C组排卵前单卵泡FF的AMH水平比较,差异无显著性(54.77ng/gpro和64.05ng/gpro;P>0.05),但显著高于A组(29.45ng/gpro;P<0.05)。结论多囊卵巢患者血清AMH水平升高,其颗粒细胞可能存在AMH分泌异常,但多囊卵巢患者AMH水平的增高可能不是造成卵泡生长停滞的原因。

引用

页码：346 / 349

页数：4

共 5 条

[1]

Per-follicle measurements indicate that anti-müllerian hormone secretion is modulated by the extent of follicular development and luteinization and may reflect qualitatively the ovarian follicular status.[J]..Fertility and Sterility.2005, 1

[2]

Anti-Müllerian Hormone Serum Concentrations in Normoovulatory and Anovulatory Women of Reproductive Age.[J].Joop S. E. Laven;Annemarie G. M. G. J. Mulders;Jenny A. Visser;Axel P. Themmen;Frank H. de Jong;Bart C. J. M. Fauser.The Journal of Clinical Endocrinology & Metabolism.2004, 1

[3]

Elevated serum level of anti-Mullerian hormone in patients with polycystic ovary syndrome: Relationship to the ovarian follicle excess and to the follicular arrest [J].

Pigny, P ;

Merlen, E ;

Robert, Y ;

Cortet-Rudelli, C ;

Decanter, C ;

Jonard, S ;

Dewailly, D .

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2003, 88 (12) :5957-5962

[4]

Antimüllerian hormone serum levels: a putative marker for ovarian aging.[J].Annemarie de Vet;Joop S.E. Laven;Frank H. de Jong;Axel P.N. Themmen;Bart C.J.M. Fauser.Fertility and Sterility.2002, 2

[5]

Müllerian-inhibiting substance in follicular fluid and serum: a comparison of patients with tubal factor infertility; polycystic ovary syndrome; and endometriosis.[J].Mary E. Fallat;Yong Siow;Maureen Marra;Christine Cook;Alberto Carrillo.Fertility and Sterility.1997, 5

← 1 →