血浆血栓调节蛋白水平与冠心病关系的研究

被引：8

作者：

章宏祥

段宝祥

毛建华

陈绍良

机构：

[1] 马鞍山马钢医院心内科

[2] 南京医科大学附属南京第一医院心内科安徽马鞍山

[3] 安徽马鞍山

来源：

心血管康复医学杂志 | 2004年 / 05期

关键词：

血栓调节蛋白; 冠心病; 内皮细胞;

D O I：

暂无

中图分类号：

R541.4 [冠状动脉（粥样）硬化性心脏病（冠心病）];

学科分类号：

1002 ; 100201 ;

摘要：

目的:分别测定正常人及冠心病患者的血浆血栓调节蛋白(Thrombomodulin,TM)含量并探讨及与冠心病的关系。方法:观察对象分成正常对照组,稳定性心绞痛(SAP)组,不稳定性心绞痛(UAP)组及急性心肌梗死(AMI)组。采用酶联免疫吸附试验测量血浆TM值。结果:UAP组及AMI组TM水平无显著性差异(P=0.711),但这两组TM水平均明显高于SAP组及正常对照组(P<0.01),SAP组TM水平又高于正常对照组(P=0.05)。结论:血浆血栓调节蛋白水平是反映冠心病患者内皮细胞损伤程度和范围以及冠脉斑块稳定性的良好指标,对急性冠脉综合征与SAP的鉴别有较好的价值。

引用

页码：432 / 434

页数：3

共 7 条

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