非甾体抗炎药的研究与开发

[1] Cronlish WA,Kennedy BP.Selective inhibitors of cyclooxygenase-1 and-2 using intact insect cell assays. Biochemical Pharmacology . 1995

[2] Kalgutkar AS,Kozak KR,Crews BC,et al.Convalent modification of cyclooxygenase-2 by 2-acetoxyphenyl alkyl sulfides , a new class of selective COX-2 inactives. Journal of Medicinal Chemistry . 1998

[3] Wallace JJ,Elliott SN,Soldato DD,et al.Gastrointestinal-sparing antiinflammatory drugs: the development of Nitric Oxide-releasing NSAIDs. Drug Development Research . 1997

[4] Li JJ,Norton MB,Reinhard EJ,et al.Novel terphenyls as selective cyclooxygenase-2 inhibitors and orally active antiinflammatory agents. Journal of Medicinal Chemistry . 1996

[5] Moncada S,Palmer RMJ,Higgs EA.Nitric oxide: physiology, pathophysiology, and pharmacology. Pharmacology Reviews . 1991

[6] Chan CC,Boyce S,Bridean C,et al.Pharmacology of a selective cyclooxygenase-2 inhibitor, L-745337: a novel nonsteroidal antiinflammatory agent with an ulcerogenic sparing effect in rat and nonhuman primate stomach. Journal of Pharmacology and Experimental Therapeutics . 1995

[7] Li CS,Black WC,Chan CC,et al.Cyclooxygenase-2 inhibitors: synthesis and pharmocological activities of 5methanesulfonamido-1-indadone derivatives. Journal of Medicinal Chemistry . 1995

[8] Jouzeau JY,Terlain B,Abid A,et al.Cyclo-oxygenase isoenzymes: how recent findings affect thinking about nonsteroidal anti-Inflammatory drugs. Drugs . 1997

[9] Kenneth,Kun-Yu Wu.Biochemical pharmacology of nonsteroidal antiinflammatory drugs. Biochemical Pharmacology . 1998

[10] Raz A,Wyche A,Needleman P,et al.Temporal and pharmacological division of fibrolast cyclooxygenase expression intotranscriptional and transcriptional phases. Proceedings of the National Academy of Sciences of the United States of America . 1989

[1] Cronlish WA,Kennedy BP.Selective inhibitors of cyclooxygenase-1 and-2 using intact insect cell assays. Biochemical Pharmacology . 1995

[2] Kalgutkar AS,Kozak KR,Crews BC,et al.Convalent modification of cyclooxygenase-2 by 2-acetoxyphenyl alkyl sulfides , a new class of selective COX-2 inactives. Journal of Medicinal Chemistry . 1998

[3] Wallace JJ,Elliott SN,Soldato DD,et al.Gastrointestinal-sparing antiinflammatory drugs: the development of Nitric Oxide-releasing NSAIDs. Drug Development Research . 1997

[4] Li JJ,Norton MB,Reinhard EJ,et al.Novel terphenyls as selective cyclooxygenase-2 inhibitors and orally active antiinflammatory agents. Journal of Medicinal Chemistry . 1996

[5] Moncada S,Palmer RMJ,Higgs EA.Nitric oxide: physiology, pathophysiology, and pharmacology. Pharmacology Reviews . 1991

[6] Chan CC,Boyce S,Bridean C,et al.Pharmacology of a selective cyclooxygenase-2 inhibitor, L-745337: a novel nonsteroidal antiinflammatory agent with an ulcerogenic sparing effect in rat and nonhuman primate stomach. Journal of Pharmacology and Experimental Therapeutics . 1995

[7] Li CS,Black WC,Chan CC,et al.Cyclooxygenase-2 inhibitors: synthesis and pharmocological activities of 5methanesulfonamido-1-indadone derivatives. Journal of Medicinal Chemistry . 1995

[8] Jouzeau JY,Terlain B,Abid A,et al.Cyclo-oxygenase isoenzymes: how recent findings affect thinking about nonsteroidal anti-Inflammatory drugs. Drugs . 1997

[9] Kenneth,Kun-Yu Wu.Biochemical pharmacology of nonsteroidal antiinflammatory drugs. Biochemical Pharmacology . 1998

[10] Raz A,Wyche A,Needleman P,et al.Temporal and pharmacological division of fibrolast cyclooxygenase expression intotranscriptional and transcriptional phases. Proceedings of the National Academy of Sciences of the United States of America . 1989