视黄醇结合蛋白4与非酒精性脂肪肝病的相关研究

被引：10

作者：

刘滨菘 ^{[1
]}

李强 ^{[1
]}

王薇 ^{[1
]}

郭琳 ^{[1
]}

王晶 ^{[1
]}

刘姝 ^{[1
]}

张巾超 ^{[1
]}

机构：

[1] 哈尔滨医科大学附属第二医院内分泌代谢病科、哈尔滨医科大学激素与内分泌疾病重点实验室

来源：

中华内分泌代谢杂志 | 2013年 / 01期

关键词：

非酒精性脂肪性肝病; 视黄醇结合蛋白4; 糖尿病; 2型;

D O I：

暂无

中图分类号：

R575.5 [肝代谢障碍];

学科分类号：

1002 ; 100201 ;

摘要：

从住院患者和体验人群中共选取261例研究对象,分为正常对照组(NC)、单纯非酒精性脂肪性肝病组(NAFLD)、单纯2型糖尿病组(T2DM组)、2型糖尿病伴NAFLD组(DMN组);2型糖尿病患者再按肝脏超声结果再分为无NAFLD组、轻度脂肪浸润组(NAFLD-L组)、中度脂肪浸润组(NAFLD-M组)、重度脂肪浸润组(NAFLD-S组)。测定空腹血糖、血脂、肝肾功能、视黄醇结合蛋白4(RBP4)等,通过方差分析、相关分析、logistic回归分析评价各指标对NAFLD的影响。结果显示,伴或不伴NAFLD的2型糖尿病患者空腹血糖水平显著高于NC组及单纯NAFLD组(P<0.01);DMN组甘油三酯(TG)水平显著高于其他3组(均P<0.01),而高密度脂蛋白胆固醇(HDL-C)水平低于其他3组(均P<0.01);DMN组的收缩压及舒张压均高于NC组及T2DM组(P<0.05或P<0.01);NAFLD患者血清RBP4水平较非NAFLD者高[45.00(38.75,51.00)mg/L对50.00(43.00,62.00)mg/L,P<0.01],并随着NAFLD的加重而升高[NAFLD-L组44.00(37.00,51.00)mg/L、NAFLD-M组52.00(46.00,63.00)mg/L、NAFLD-S组78.5(72.75,83.00)mg/L,均P<0.01]。Logtstic分析显示血清RBP4与NAFLD显著相关(P=0.029)。此外,血清RBP4水平与体重指数、腰臀比、γ-谷氨转肽酶、总胆固醇、TG、谷草转氨酶、谷丙转氨酶、前白蛋白、肌酐、尿素及尿酸相关(P<0.05或P<0.01)。这些结果提示血清RBP4可能是NAFLD的危险因素之一。

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