TLR4信号转导通路与骨关节炎

被引:12
作者
敏思聪
俞银贤
马金忠
机构
[1] 上海交通大学附属第一人民医院骨科
关键词
Toll样受体; 骨关节炎; 信号通路;
D O I
暂无
中图分类号
R684.3 [关节炎];
学科分类号
100220 [骨科学];
摘要
Toll样受体(TLR)家族重要成员TLR4,在基质金属蛋白酶、促炎症因子等导致的骨关节炎软骨退变病理进程中起重要的介导作用,对软骨细胞凋亡、细胞外基质代谢失衡具有关键作用。深入研究TLR4信号转导通路与骨关节炎的关系,有助于为骨关节炎防治研究开辟新途径。该文就TLR4信号通路与骨关节炎发病机制相关性研究进展作一综述。
引用
收藏
页码:266 / 268
页数:3
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