早期即刻基因与老年性痴呆

被引:7
作者
王磊 [1 ]
王鲁宁 [2 ]
叶玲 [2 ]
机构
[1] 第二炮兵总医院神经内科
[2] 解放军总医院老年医学研究所
关键词
Alzheimer病; 早期即刻基因; 表达;
D O I
10.16636/j.cnki.jinn.2002.03.030
中图分类号
R749.1 [脑器质性精神障碍];
学科分类号
100205 ;
摘要
早期即刻基因(c-fos)在脑中参与神经元的信号转导及凋亡过程,认为其与认知功能和学习记忆有关,c-fos基因表达对长期记忆的保持是必须的;Alzheimer病患者大脑皮层及海马中发现c-fos过度表达,推测c-fos可能在AD的病理中起一定作用。了解c-fos的生理特性、研究c-fos与学习记忆的关系、探讨c-fos基因突变在AD发病中的作用,将对明确AD的发病机理、寻求防治原则提供参考依据。
引用
收藏
页码:277 / 279
页数:3
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