生酮饮食治疗癫痫的神经保护作用

被引：9

作者：

陈鑫

周晓平

机构：

[1] 上海长海医院神经外科一病区

来源：

中华神经医学杂志 | 2010年 / 04期

关键词：

生酮饮食; 癫痫; 抗癫痫药物;

D O I：

暂无

中图分类号：

R742.1 [癫痫];

学科分类号：

100204 [神经病学];

摘要：

<正>近年来抗癫痫药物(AEDs)得到很大的发展和深入研究,但AEDs治疗通常面临着很多显著的副作用,仍有很多类型的癫痫无法控制。19世纪90年代以来,生酮饮食(ketogenicdiet,KD)已成为有效治疗癫痫的方法之一,尤其是在难控制的癫痫和减少药物副作用方面。研究表明,对于儿童难治性癫痫的治疗,KD比AEDs更为有效。KD是一种营养均衡的以脂肪为主的饮食,已被FDA认证并列为控制儿童顽固性癫痫的医疗食品。本文就KD用于治疗癫痫的神经保护作用进行综述。

引用

共 13 条

[1]

Ketogenic diet increases calbindin-D28k in the hippocampi of male ICR mice with kainic acid seizures [J].

Noh, HS ;

Kang, SS ;

Kim, DW ;

Kim, YH ;

Park, CH ;

Han, JY ;

Cho, GJ ;

Choi, WS .

EPILEPSY RESEARCH, 2005, 65 (03) :153-159

[2]

Ketogenic diet prevents clusterin accumulation induced by kainic acid in the hippocampus of male ICR mice [J].

Noh, HS ;

Kim, DW ;

Kang, SS ;

Cho, GJ ;

Choi, WS .

BRAIN RESEARCH, 2005, 1042 (01) :114-118

[3]

Ketogenic diet: Outpatient initiation, without fluid, or caloric restrictions [J].

Vaisleib, II ;

Buchhalter, JR ;

Zupanc, ML .

PEDIATRIC NEUROLOGY, 2004, 31 (03) :198-202

[4]

Caloric restriction augments brain glutamic acid decarboxylase-65 and-67 expression [J].

Cheng, CM ;

Hicks, K ;

Wang, J ;

Eagles, DA ;

Bondy, CA .

JOURNAL OF NEUROSCIENCE RESEARCH, 2004, 77 (02) :270-276

[5]

Perspectives on the metabolic management of epilepsy through dietary reduction of glucose and elevation of ketone bodies [J].

Greene, AE ;

Todorova, MT ;

Seyfried, TN .

JOURNAL OF NEUROCHEMISTRY, 2003, 86 (03) :529-537

[6]

Calorie restriction and ketogenic diet diminish neuronal excitability in rat dentate gyrus in vivo [J].

Bough, KJ ;

Schwartzkroin, PA ;

Rho, JM .

EPILEPSIA, 2003, 44 (06) :752-760

[7]

Ketogenic diet increases glutathione peroxidase activity in rat hippocampus [J].

Ziegler, DR ;

Ribeiro, LC ;

Hagenn, M ;

Siqueira, IR ;

Araújo, E ;

Torres, ILS ;

Gottfried, C ;

Netto, CA ;

Gonaalves, CA .

NEUROCHEMICAL RESEARCH, 2003, 28 (12) :1793-1797

[8]

The ketogenic diet in children, adolescents and young adults with refractory epilepsy: an Italian multicentric experience [J].

Coppola, G ;

Veggiotti, P ;

Cusmai, R ;

Bertoli, S ;

Cardinali, S ;

Dionisi-Vici, C ;

Elia, M ;

Lispi, ML ;

Sarnelli, C ;

Tagliabue, A ;

Toraldo, C ;

Pascotto, A .

EPILEPSY RESEARCH, 2002, 48 (03) :221-227

[9]

Higher ketogenic diet ratios confer protection from seizures without neurotoxicity [J].

Bough, KJ ;

Yao, SG ;

Eagles, DA .

EPILEPSY RESEARCH, 2000, 38 (01) :15-25

[10]

Timing of ketogenic diet initiation in an experimental epilepsy model.[J].Sharon W. Su;M.Roberta Cilio;Yoshimi Sogawa;Diosely Silveira;Gregory L. Holmes;Carl E. Stafstrom.Developmental Brain Research.2000, 1

← 1 2 →