醛固酮及其受体拮抗剂在心血管疾病中的研究进展附视频

被引：9

作者：

张金国 ^{[1
]}

程云涛 ^{[1
]}

刘洪岩 ^{[2
]}

董志巨 ^{[1
]}

机构：

[1] 济宁医学院附属医院心内二科

[2] 山东大学

来源：

医学综述 | 2010年 / 05期

关键词：

醛固酮; 醛固酮受体拮抗剂; 心血管疾病;

D O I：

暂无

中图分类号：

R54 [心脏、血管（循环系）疾病];

学科分类号：

100201 [内科学];

摘要：

临床和实验均已证实醛固酮对心血管系统有多种毒性作用,在心脏中它已与肾素-血管紧张素共同促成心肌纤维化、血管重塑、心室肥大和动脉硬化等改变,进一步诱发心律失常,加重心肌缺血;在冠心病领域中可作为预测不良事件发生的一个独立指标;在一定程度上反映了心房颤动患者神经激素的激活,并与代谢综合征危险因素密切相关,对心力衰竭进程及预后具有重要的预测价值。而醛固酮受体拮抗剂可以预防或延缓这些不利作用的发生,在心血管系统中将发挥重要作用。

引用

页码：728 / 731

页数：4

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