PI3K-Akt信号通路与肿瘤化疗耐药性

被引：14

作者：

姜蓬垒

常冰梅

机构：

[1] 山西医科大学生物化学与分子生物学教研室

来源：

国际肿瘤学杂志 | 2014年 / 41卷 / 05期

关键词：

信号传导; 肿瘤; 药物耐受性; 药物疗法;

D O I：

暂无

中图分类号：

R730.53 [化学（药物）疗法];

学科分类号：

100112 [医学生物化学与分子生物学];

摘要：

磷脂酰肌醇3-激酶-蛋白激酶B（PI3K-Akt）信号通路对于细胞增殖、分化、凋亡的调节起关键性作用,与细胞的生理功能和某些疾病的发生关系密切。在许多肿瘤中,PI3K-Akt信号通路的过度激活与肿瘤耐药性的产生也密切相关。体外研究表明,使用化疗药物联合PI3K-Akt信号通路抑制剂,可以显著增强化疗药物作用效果、降低IC50值。因此,PI3K-Akt信号通路已成为一个可以逆转化疗耐药的重要靶点。

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