全胸腔镜肺叶切除术治疗早期非小细胞性肺癌的效果分析

被引：12

作者：

曾颖鸥

罗清泉

机构：

[1] 上海第六人民医院南院心胸外科

来源：

中国医药导报 | 2013年 / 10卷 / 27期

关键词：

胸腔镜; 非小细胞肺癌; 肿瘤坏死因子-α; 降钙素原; 高敏C反应蛋白;

D O I：

暂无

中图分类号：

R734.2 [肺肿瘤];

学科分类号：

100117 [系统生物医学];

摘要：

目的观察全胸腔镜和开胸肺叶切除术治疗早期非小细胞性肺癌的疗效及其对肺癌症状量表(LCSS),肿瘤坏死因子-α(TNF-α),降钙素原(PCT)和高敏C反应蛋白(hs-CRP)水平的影响。方法选取2008年1月～2012年6月在上海第六人民医院南院行手术治疗的早期非小细胞性肺癌患者214例,按照手术方式不同分为腔镜组(160例)和开胸组(54例),腔镜组予以全胸腔镜肺叶切除术,开胸组予以开胸肺叶切除术。观察两组手术时间,术中出血量,淋巴结清扫总数,术后引流时间,住院时间,下床活动时间和并发症发生率的情况和治疗前后LCSS评分,TNF-α,PCT和hs-CRP水平的变化。结果①腔镜组的手术时间、术中出血量、住院时间和下床活动时间均低于开腹组,差异有统计学意义(P<0.05或P<0.01);两组淋巴结清扫总数和术后引流时间差异无统计学意义(P>0.05)。②术后两组TNF-α、PCT和hs-CRP水平较术前明显升高,LCSS评分明显下降,差异均有统计学意义(P<0.05);术后腔镜组TNF-α、PCT、hs-CRP水平及LCSS评分低于开胸组,差异有高度统计学意义(P<0.01)。③腔镜组并发症发生率为3.75%(6/160),开胸组并发症发生率为5.55%(3/54),两组并发发生率差异无统计学意义(P>0.05)。结论与开胸肺叶切除术相比,全胸腔镜肺叶切除术具有创伤小,恢复快,提高术后生存质量,能降低机体TNF-α,PCT和hs-CRP的释放。

引用

页码：40 / 42

页数：3

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