无创高频振荡通气在中-重度慢性阻塞性肺疾病急性加重期伴呼吸衰竭患者中的应用

被引：25

作者：

王蕾 ^{[1
]}

邱宇 ^{[1
]}

王娟 ^{[1
]}

杨谨羽 ^{[1
]}

吴小玲 ^{[2
]}

机构：

[1] 绵阳市第三人民医院·四川省精神卫生中心呼吸与危重症医学科

[2] 四川大学华西医院呼吸与危重症医学科

来源：

成都医学院学报 | 2022年 / 17卷 / 01期

关键词：

慢性阻塞性肺疾病急性加重期; 无创高频振荡通气; 双相气道正压通气; 白细胞; 降钙素原; C-反应蛋白;

D O I：

暂无

中图分类号：

R563 [肺疾病];

学科分类号：

100201 [内科学];

摘要：

目的研究无创高频振荡通气治疗对中-重度慢性阻塞性肺疾病急性加重期(AECOPD)伴呼吸衰竭患者炎性指标及痰液性状的影响。方法选取2019年1月至2020年6月在绵阳市第三人民医院·四川省精神卫生中心呼吸与危重症医学科就诊的100例中-重度AECOPD伴呼吸衰竭患者为研究对象,按随机数字表法分为双相气道正压通气(BiPAP)组和无创高频振荡通气(NHFOV)组,每组50例。两组于治疗前及治疗后72 h采集清晨空腹静脉血,经全自动血液分析仪检测白细胞(WBC)水平,透射比浊法检测患者C-反应蛋白(CRP)水平,电化学发光法检测患者降钙素原(PCT)水平,比较两组WBC、CRP、PCT等炎症指标;痰液量、性状及颜色改变。结果治疗后,NHFOV组PCT、CRP值明显低于BiPAP组(P<0.05);两组WBC比较,差异无统计学意义(P>0.05);NHFOV组痰液性状改变时间、平均24 h排痰量较BiPAP组明显降低(P<0.05)。结论在中-重度AECOPD伴呼吸衰竭患者治疗中,NHFOV较常规BiPAP更能减轻炎性反应,减少痰液量,改善患者症状。

引用

收藏

页码：16 / 20

页数：5

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