创伤性脑损伤患者血清泛素羧基末端水解酶L1和神经元特异性烯醇化酶含量测定及临床意义

被引：10

作者：

余万

黄保胜

陆晓诚

唐琳俊

李立新

机构：

[1] 南京医科大学第一附属医院神经外科

来源：

江苏医药 | 2014年 / 40卷 / 07期

关键词：

创伤性脑损伤; 泛素羧基末端水解酶; 神经元特异性烯醇化酶;

D O I：

10.19460/j.cnki.0253-3685.2014.07.009

中图分类号：

R651.15 [];

学科分类号：

摘要：

目的测定创伤性脑损伤患者血清泛素羧基末端水解酶L1(UCH-L1)和神经元特异性烯醇化酶(NSE)的含量,探讨其临床意义。方法选择创伤性脑损伤患者55例,按格拉斯哥昏迷评分(GCS)分轻中度组(9-15分,25例)和重度组(3-8分,30例);选择30例正常体检者作为对照组。采集伤后12h静脉血,以ELISA法测定三组血清UCH-L1及NSE的含量,分析其与损伤程度及预后的关系。结果与对照组相比,轻中度、重度组患者伤后12h血清UCH-L1及NSE浓度升高(P<0.05);且重度组高于轻中度组(P<0.05)。血清UCH-L1及NSE水平与创伤性脑损伤患者的预后呈负相关(r=-0.657,r=-0.728,P<0.01)。结论创伤性脑损伤患者血清UCH-L1和NSE检测有助于判断损伤程度和预后。

引用

页码：771 / 773

页数：3

共 7 条

[1]

D-二聚体和C反应蛋白在脑外伤后的表达变化及临床意义 [J].

邓引生 ;

焦磊 ;

吴旻 ;

蒋明 ;

庄严 .

江苏医药, 2013, 39 (16) :1906-1908

[2]

Neuron-Specific Enolase, S100B, and Glial Fibrillary Acidic Protein Levels as Outcome Predictors in Patients With Severe Traumatic Brain Injury [J].

Boehmer, Ana Elisa ;

Oses, Jean Pierre ;

Schmidt, Andre Prato ;

Peron, Cleiton Schweister ;

Krebs, Claudio Liss ;

Oppitz, Paulo Petry ;

D'Avila, Thiago Torres ;

Souza, Diogo Onofre ;

Portela, Luis Valmor ;

Stefani, Marco Antonio .

NEUROSURGERY, 2011, 68 (06) :1624-1630

[3]

Clinical applications of biomarkers in pediatric traumatic brain injury [J].

Sandler, Simon J. I. ;

Figaji, Anthony A. ;

Adelson, P. David .

CHILDS NERVOUS SYSTEM, 2010, 26 (02) :205-213

[4]

Traumatic brain injury: the signature of modern conflicts [J].

Hayward, Peter .

LANCET NEUROLOGY, 2008, 7 (03) :200-201

[5]

Serum neuron-specific enolase as a predictor of short-term outcome and its correlation with Glasgow Coma Scale in traumatic brain injury [J].

Guzel, Aslan ;

Er, Uygur ;

Tatli, Mehmet ;

Aluclu, Ufuk ;

Ozkan, Umit ;

Duzenli, Yucel ;

Satici, Omer ;

Guzel, Ebru ;

Kemaloglu, Serdar ;

Ceviz, Adnan ;

Kaplan, Abdurrahman .

NEUROSURGICAL REVIEW, 2008, 31 (04) :439-444

[6]

The functions of UCH-L1 and its relation to neurodegenerative diseases.[J].Rieko Setsuie;Keiji Wada.Neurochemistry International.2007, 2

[7]

The demonstration of new human brain-specific proteins by high-resolution two-dimensional polyacrylamide gel electrophoresis..Peter Jackson;R.J. Thompson;.Journal of the Neurological Sciences.1981, 03

← 1 →