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- [2] Natural history of inoperable hepatocellular carcinoma: Estrogen receptors’ status in the tumor is the strongest prognostic factor for survival[J] . Erica Villa,Anna Moles,Ilva Ferretti,Paola Buttafoco,Antonella Grottola,Mariagrazia Del Buono,Mario De Santis,Federico Manenti.Hepatology . 2000 (2)