抑郁症的事件相关脑电位P300实验研究

被引:8
作者
张新凯
张明园
陈兴时
机构
[1] 上海交通大学医学院附属精神卫生中心
关键词
抑郁症; 事件相关脑电位; P300;
D O I
暂无
中图分类号
R749.4 [情感性精神病];
学科分类号
100204 [神经病学];
摘要
目的探讨抑郁症听觉事件相关电位P300的变化特点。方法对35例抑郁症患者和31名健康成年人,应用美国Nicolet Bravo脑诱发电位仪进行P300检测。结果与正常组相比,抑郁症组Oz点P3潜伏期延迟[正常组(315±29)ms,抑郁症组(341±31)ms,t=3.50,P<0.01],P2潜伏期延迟[正常组(165±19)ms,抑郁症组(175±21)ms,t=2.02,P<0.05],P3波幅降低[正常组(9.5±6.1)μV,抑郁症组(4.5±3.1)μV,t=4.27,P<0.01],非靶P2波幅降低[正常组(4.2±1.2)μV,抑郁症组(2.3±1.3)μV,t=6.14,P<0.01]。结论P300是评定抑郁症患者大脑综合功能的有效工具,在临床上值得进一步推广应用。
引用
收藏
页码:20 / 22
页数:3
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