细胞凋亡在非酒精性脂肪性肝炎发病机制中的作用

被引：2

作者：

张静 ^{[1
]}

赵景民 ^{[2
]}

机构：

[1] 军事医学科学院

[2] 解放军第三○二医院

来源：

传染病信息 | 2008年 / 03期

关键词：

细胞凋亡; 纤维化; 炎症反应; 非酒精性脂肪性肝; HSC; 单纯性脂肪肝; 凋亡小体; 发病机制;

D O I：

暂无

中图分类号：

R575.1 [肝炎];

学科分类号：

1002 ; 100201 ;

摘要：

<正>非酒精性脂肪性肝病(NAFLD)包括了肝脏损伤的一个广泛的疾病谱:从单纯性脂肪肝到非酒精性脂肪性肝炎(NASH),继之可进展为肝硬化和终末期肝病[1]。单纯性脂肪肝是一种良性少进展的病

引用

页码：150 / 152

页数：3

共 7 条

[1]

Natural History of NAFLD: Remarkably Benign in the Absence of Cirrhosis[J] . C.P. Day.Gastroenterology . 2005 (1)

[2] Hepatocyte apoptosis and Fas expression are prominent features of human nonalcoholic steatohepatitis [J].

Feldstein, AE ;

Canbay, A ;

Angulo, P ;

Taniai, M ;

Burgart, LJ ;

Lindor, KD ;

Gores, GJ .

GASTROENTEROLOGY, 2003, 125 (02) :437-443

[3]

Fas enhances fibrogenesis in the bile duct ligated mouse: A link between apoptosis and fibrosis[J] . Ali Canbay,Hajime Higuchi,Steven F. Bronk,Makiko Taniai,Tom J. Sebo,Gregory J. Gores.Gastroenterology . 2002 (4)

[4]

Gene expression of tumor necrosis factor[alpha] and TNF-receptors, p55 and p75, in nonalcoholic steatohepatitis patients[J] . Javier Crespo,Amal[iacute]a Cay[oacute]n,Pedro Fern[aacute]ndez-Gil,Manuel Hern[aacute]ndez-Guerra,Marta Mayorga,Agust[iacute]n Dom[iacute]nguez-D[iacute]ez,Jos[eacute] Carlos Fern[aacute]ndez-Escalante,Fernando Pons-Romero.Hepatology . 2001 (6)

[5] Etiopathogenesis of nonalcoholic steatohepatitis [J].

Chitturi, S ;

Farrell, GC .

SEMINARS IN LIVER DISEASE, 2001, 21 (01) :27-41

[6]

Nuclear factor κB in proliferation, activation, and apoptosis in rat hepatic stellate cells[J] . Alon Lang,Robert Schoonhoven,Shmuel Tuvia,David A Brenner,Richard A Rippe.Journal of Hepatology . 2000 (1)

[7]

In vivo inhibition of rat stellate cell activation by soluble transforming growth factor beta type II receptor: a potential new therapy for hepatic fibrosis .2 George J,Roulot D,Koteliansky VE,et al. Proceedings of the National Academy of Sciences of the United States of America . 1999

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