家鸽实验性主动脉粥样硬化的病理形态学研究

被引:2
作者
徐增绶
邓仲端
李丽珠
王燕丽
邱红明
机构
[1] 同济医科大学基础医学部病理解剖学教研室
关键词
家鸽; 实验性动脉粥样硬化; 巨噬细胞源性和肌源性泡沫细胞; 病理形态学研究;
D O I
暂无
中图分类号
学科分类号
摘要
本实验对喂以胆固醇和猪油的幼家鸽主动脉进行光镜及电镜研究。动物于不同间隔时间处死。实验2周出现早期病变,病变随实验时间的延长而加重;24周以后,出现少数几乎阻塞血管管腔的大斑块。典型斑块由巨噬细胞源性和肌源性两种泡沫细胞组成。实验表明,家鸽具有来源充裕、饲养方便、给药方法简单、剂量控制准确,又能早期有效地诱发主动脉粥样硬化等优点,可作为一种比较理想的动物模型。
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页码:11 / 14+75 +75
页数:5
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