微透析技术结合色-质联用检测细胞外液神经递质研究进展

被引：1

作者：

王杰琼

张惠云

机构：

[1] 山东中医药大学中医药经典理论教育部重点实验室

来源：

医学综述 | 2011年 / 17卷 / 07期

关键词：

体内微透析; 色-质联用技术; 神经递质;

D O I：

暂无

中图分类号：

R741 [神经病学];

学科分类号：

1002 ;

摘要：

近30年,关于神经递质化学作用的大量信息被发现,同时也暴露出神经环路的复杂本性,多重神经递质系统间的交互作用以及不同受体对应神经化学物质的复杂效应。微透析已作为常规的测量活体组织系统的神经递质水平的实验技术,并在研究神经变性和精神性疾病机制以及鉴别治疗这些疾病的新药方面表现出特有的优势。而微透析取样技术与现代分析技术联用已成为生物学、医学、药学研究的强有力手段。最近,对体内收集的微透析液的分析,大多数聚焦在色-质联用技术的发展上,该技术能够给予更加灵敏和准确的神经递质的分析测量方法。现主要综述与精神神经疾病联系比较密切的几种细胞外液神经递质的检测方法。

引用

页码：1052 / 1055

页数：4

共 8 条

[1]

Enantiomeric separation of amino acids derivatized with 7-fluoro-4-nitrobenzoxadiazole by capillary liquid chromatography/tandem mass spectrometry[J] . Yaru Song,Ming Shenwu,Shulin Zhao,Dongyan Hou,Yi-Ming Liu.Journal of Chromatography A . 2005 (1)

[2]

Dihydropiridines Mechanism of Action in Striatal Isolated Nerve Endings: Comparison with ω-Agatoxin IVA[J] . C. A. Galindo,M. Sitges.Neurochemical Research . 2004 (4)

[3]

High-performance liquid chromatography/tandem mass spectrometric assay for the simultaneous measurement of dopamine, norepinephrine, 5-hydroxytryptamine and cocaine in biological samples[J] . Mark E.P. Hows,Laurent Lacroix,Christian Heidbreder,Andrew J. Organ,Ajit J. Shah.Journal of Neuroscience Methods . 2004 (1)

[4] Clinical spectrum of succinic semialdehyde dehydrogenase deficiency [J].

Pearl, PL ;

Gibson, KM ;

Acosta, MT ;

Vezina, LG ;

Theodore, WH ;

Rogawski, MA ;

Novotny, EJ ;

Gropman, A ;

Conry, JA ;

Berry, GT ;

Tuchman, M .

NEUROLOGY, 2003, 60 (09) :1413-1417

[5]

Development and application of a sensitive high performance ion-exchange chromatography method for the simultaneous measurement of dopamine, 5-hydroxytryptamine and norepinephrine in microdialysates from the rat brain[J] . Christian A. Heidbreder,Laurent Lacroix,Alan R. Atkins,Andrew J. Organ,Sarah Murray,Andrew West,Ajit J. Shah.Journal of Neuroscience Methods . 2001 (2)

[6]

Simultaneous determination of γ-aminobutyric acid and glutamic acid in the brain of 3-mercaptopropionic acid-treated rats using liquid chromatography–atmospheric pressure chemical ionization mass spectrometry[J] . Deshun Ma,Jianying Zhang,Kazunori Sugahara,Tomiko Ageta,Kazuko Nakayama,Hiroyuki Kodama.Journal of Chromatography B: Biomedical Sciences and Applications . 1999 (1)

[7]

The rapid determination of γ-aminobutyric acid[J] . Guijin Zhang,Alan W. Bown.Phytochemistry . 1997 (6)

[8] DETECTION OF BASAL ACETYLCHOLINE IN RAT-BRAIN MICRODIALYSATE [J].

HUANG, TH ;

YANG, L ;

GITZEN, J ;

KISSINGER, PT ;

VREEKE, M ;

HELLER, A .

JOURNAL OF CHROMATOGRAPHY B-BIOMEDICAL APPLICATIONS, 1995, 670 (02) :323-327

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