银屑病Th1/Th2模式的体外试验

被引:6
作者
阎衡
叶庆佾
郝飞
项贵明
黄东平
麦跃
机构
[1] 第三军医大学附属西南医院皮肤科
[2] 第三军医大学附属新桥医院检验科
[3] 第三军医大学附属西南医院皮肤科 重庆
[4] 重庆
关键词
银屑病; Th1/Th2; 细胞因子; 葡萄球菌肠毒素B;
D O I
10.16016/j.1000-5404.2001.11.040
中图分类号
R758.63 [牛皮癣(银屑病)];
学科分类号
100206 ;
摘要
目的 研究银屑病的Th1/Th2反应模式。方法 标本取自 33例寻常型银屑病患者和 2 0名正常对照者 ,利用植物血凝素 (PHA)和葡萄球菌肠毒素B(SEB)分别刺激外周血单个核细胞增殖 ,通过ELISA法检测PBMC培养上清中IL 2、IFN γ和IL 4水平。结果 SEB显著促进银屑病组 3种细胞因子的分泌 (P <0 .0 1) ;SEB和PHA刺激组中 ,进行期IFN γ/IL 4的比值均明显高于静止期 (P <0 .0 1)。结论 银屑病属于Th1型反应模式。
引用
收藏
页码:1335 / 1336
页数:2
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