PGE2/EP信号通路在肺部疾病中作用的研究进展

被引：5

作者：

陈建安 ^{[1
]}

李德富 ^{[1
]}

袁良 ^{[2
]}

易高 ^{[1
]}

机构：

[1] 广州医科大学附属第五医院呼吸内科

[2] 广州医科大学附属第一医院呼吸内科

来源：

国际呼吸杂志 | 2020年 / 40卷 / 12期

基金：

广东省自然科学基金;

关键词：

前列腺素E2/前列腺素E受体信号通路; 肺肿瘤; 急性肺损伤; 肺疾病, 慢性阻塞性; 过敏性哮喘;

D O I：

暂无

中图分类号：

R563 [肺疾病];

学科分类号：

100201 [内科学];

摘要：

前列腺素E2(PGE2)由花生四烯酸代谢而成, 含有4个碳-碳双键, 为高级不饱和脂肪酸。PGE2能在多种细胞中产生并作用于不同类型的前列环素受体(EP), 在调节心血管系统及维持水盐内环境稳态中起重要作用。近年来, 越来越多的研究表明PGE2/EP信号通路在慢性阻塞性肺疾病中发挥着重要作用, 且其在哮喘、肺癌以及急性肺损伤中可能均起到一定的作用。本文将对PGE2/EP信号通路在各种肺部疾病中的作用进行综述。

引用

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