重度烧伤大鼠骨骼肌胰岛素抵抗的研究

被引:8
作者
许霖水
吴喜贵
董燕麟
机构
[1] 第三军医大学生化教研室
关键词
胰岛素抵抗; 大鼠; 骨骼肌细胞膜; 重度烧伤;
D O I
暂无
中图分类号
学科分类号
摘要
本文观察30%体表面积(TBSA)Ⅲ度烫伤对大鼠骨骼肌细胞膜胰岛素受体结合活性和离体比目鱼肌2-脱氧葡萄糖摄取和胰岛素的影响。结果表明,伤后大鼠骨骼肌胰岛素受体最大结合率变化不明显,但受体结合容量明显减少。离体比目鱼肌对2-脱氧葡萄糖基础摄取无明显改变,但胰岛素刺激效应明显降低。提示重度烧伤大鼠由于损伤及未损伤肌肉组织对胰岛素刺激的反应性降低而出现胰岛素抵抗,它可能与胰岛素受体减少有关。
引用
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页码:87 / 90
页数:4
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