髓样分化因子88的研究进展:把握TLR信号通路中的瓶颈

被引：22

作者：

章烈 ^{[1
,2
]}

李园 ^{[2
,3
]}

周总光 ^{[1
,2
]}

机构：

[1] 四川大学华西医院胃肠外科中心

[2] 四川大学华西医院消化外科实验室

[3] 四川大学华西医院小儿外科

来源：

中国普外基础与临床杂志 | 2013年 / 20卷 / 06期

基金：

国家自然科学基金重点项目;

关键词：

髓样分化因子88; Toll样受体; 信号通路; 接头蛋白; 应用价值;

D O I：

暂无

中图分类号：

R392.11 [免疫分子生物学（免疫化学）];

学科分类号：

100108 [医学免疫学];

摘要：

目的总结髓样分化因子88(myeloid differentiation factor 88,MyD88)在Toll样受体(toll like receptor,TLR)信号通路中的作用、MyD88与相关疾病的关系及其潜在的应用价值。方法收集近年来国内外有关MyD88在TLR信号通路中的作用及其与相关疾病关系的文献并作综述。结果 MyD88是一种重要的接头蛋白,在TLR信号通路中处于节点位置,起到承上启下的作用,是通路中的"瓶颈"。其传导的信号可导致下游多种转录因子的激活,从而启动先天性免疫反应,并且其与多种疾病的发生均有关。结论 MyD88是TLR信号通路的核心接头蛋白,在先天性免疫、获得性免疫和多种疾病的发生中均起着重要作用,是一个潜在的临床疾病的治疗靶点。

引用

页码：685 / 690

页数：6

共 13 条

[1]

Role of the Toll Like Receptor (TLR) Radical Cycle in Chronic Inflammation: Possible Treatments Targeting the TLR4 Pathway [J].

Lucas, Kurt ;

Maes, Michael .

MOLECULAR NEUROBIOLOGY, 2013, 48 (01) :190-204

[2]

Suppression of TLR Signaling by Targeting TIR domain-Containing Proteins [J].

Fekonja, Ota ;

Avbelj, Monika ;

Jerala, Roman .

CURRENT PROTEIN & PEPTIDE SCIENCE, 2012, 13 (08) :776-788

[3]

MyD88-dependent interleukin-10 production from regulatory CD11b+Gr-1high cells suppresses development of acute cerulein pancreatitis in mice [J].

Koike, Yuji ;

Kanai, Takanori ;

Saeki, Keita ;

Nakamura, Yuji ;

Nakano, Masaru ;

Mikami, Yohei ;

Yamagishi, Yoshiyuki ;

Nakamoto, Nobuhiro ;

Ebinuma, Hirotoshi ;

Hibi, Toshifumi .

IMMUNOLOGY LETTERS, 2012, 148 (02) :172-177

[4]

MyD88 mediated inflammatory signaling leads to CaMKII oxidation, cardiac hypertrophy and death after myocardial infarction [J].

Singh, Madhu V. ;

Swaminathan, Paari D. ;

Luczak, Elizabeth D. ;

Kutschke, W. ;

Weiss, Robert M. ;

Anderson, Mark E. .

JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY, 2012, 52 (05) :1135-1144

[5]

MyD88 and Trif Signaling Play Distinct Roles in Cardiac Dysfunction and Mortality during Endotoxin Shock and Polymicrobial Sepsis [J].

Feng, Yan ;

Zou, Lin ;

Zhang, Ming ;

Li, Yan ;

Chen, Chan ;

Chao, Wei .

ANESTHESIOLOGY, 2011, 115 (03) :555-567

[6]

Human TLRs and IL-1Rs in Host Defense: Natural Insights from Evolutionary; Epidemiological; and Clinical Genetics.[J].Jean-Laurent Casanova;Laurent Abel;Lluis Quintana-Murci.Annual Review of Immunology.2011, 1

[7]

Toll-Like Receptor Signaling Pathways—Therapeutic Opportunities.[J].Jiankun Zhu;Chandra Mohan;Philipp M. Lepper.Mediators of Inflammation.2010,

[8]

Monogenic IL-1 mediated autoinflammatory and immunodeficiency syndromes: Finding the right balance in response to danger signals [J].

Henderson, Cailin ;

Goldbach-Mansky, Raphaela .

CLINICAL IMMUNOLOGY, 2010, 135 (02) :210-222

[9]

The Interleukin‐1 Receptor Family.[J].Diana Boraschi;Aldo Tagliabue.Vitamins and Hormones.2006,

[10]

Modulation of Toll–interleukin 1 receptor mediated signaling [J].

Xiaoxia Li ;

Jinzhong Qin .

Journal of Molecular Medicine, 2005, 83 :258-266

← 1 2 →