曲美他嗪的临床应用与研究进展

被引：19

作者：

罗先虎 ^{[1
]}

罗勇 ^{[2
]}

机构：

[1] 重庆协和医院

[2] 川北医学院附属医院心内科

来源：

实用心脑肺血管病杂志 | 2009年 / 17卷 / 12期

关键词：

曲美他嗪; 抗心肌缺血; 临床应用;

D O I：

暂无

中图分类号：

R96 [药理学];

学科分类号：

100602 ; 100706 ;

摘要：

曲美他嗪(trimetazidine,TMZ)是一种新型的抗心肌缺血药物,能够优化心肌细胞的能量代谢,保护缺氧心肌细胞,抑制氧化应激,改善心脏功能。目前,TMZ广泛应用于心血管系统疾病。最近研究,TMZ还应用于除心血管系统方面以外的其他系统疾病,现对此作一综述。

引用

页码：1114 / 1117

页数：4

共 9 条

[1]

Trimetazidine, a Metabolic Modulator, Has Cardiac and Extracardiac Benefits in Idiopathic Dilated Cardiomyopathy[J] . Circulation . 2008 (12)

[2] Effects of trimetazidine on myocardial perfusion and left ventricular systolic function in type 2 diabetic patients with ischemic cardiomyopathy [J].

Belardinelli, Romualdo ;

Cianci, Giovanni ;

Gigli, Mirko ;

Mazzanti, Marco ;

Lacalaprice, Francesca .

JOURNAL OF CARDIOVASCULAR PHARMACOLOGY, 2008, 51 (06) :611-615

[3]

Trimetazidine and Reduction in Mortality and Hospitalization in Patients With Ischemic Dilated Cardiomyopathy: A Post Hoc Analysis of the Villa Pini D?Abruzzo Trimetazidine Trial[J] . Pericle Di Napoli,Paolo Di Giovanni,Marta Assunta Gaeta,Alfonso A Taccardi,Antonio Barsotti.Journal of Cardiovascular Pharmacology . 2007 (5)

[4] The protective effects of trimetazidine on testicular ischemia and reperfusion injury in rats [J].

Pekcetin, Cetin ;

Ergur, Bekir Ugur ;

Kiray, Muge ;

Bagriyanik, Alper ;

Tugyan, Kazim ;

Erbil, Guven ;

Ozogul, Candan .

PEDIATRIC SURGERY INTERNATIONAL, 2007, 23 (11) :1113-1118

[5] Trimetazidine administration minimizes myocardial damage and improves left ventricular function after percutaneous coronary intervention [J].

Labrou, Alexandra ;

Giannoglou, George ;

Zioutas, Dimitrios ;

Fragakis, Nikolaos ;

Katsaris, George ;

Louridas, George .

AMERICAN JOURNAL OF CARDIOVASCULAR DRUGS, 2007, 7 (02) :143-150

[6]

A Randomized Clinical Trial of Trimetazidine, a Partial Free Fatty Acid Oxidation Inhibitor, in Patients With Heart Failure[J] . Gabriele Fragasso,Altin Palloshi,Patrizia Puccetti,Carmen Silipigni,Alessandra Rossodivita,Mariagrazia Pala,Giliola Calori,Ottavio Alfieri,Alberto Margonato.Journal of the American College of Cardiology . 2006 (5)

[7] Comparison of trimetazidine plus sildenafil to chronic nitrates in the control of myocardial ischemia during sexual activity in patients with coronary artery disease [J].

Rosano, GMC ;

Marazzi, G ;

Patrizi, R ;

Cerquetani, E ;

Vitale, C ;

Volterrani, M ;

Fini, M ;

Mercuro, G .

AMERICAN JOURNAL OF CARDIOLOGY, 2005, 95 (03) :327-331

[8]

Trimetazidine induces parkinsonism,gait disorders and tremor .2 MartMassJF,MartI,Carrera N,et al. Therapie . 2005

[9]

Trimetazidine reduces oxidative stress in cardiac surgery .2 Iskesen,I,Saribulbul,O,Cerrahoglu,M,Var,A,Nazli,Y,Sirin,H. Circ J . 2006

← 1 →