胃癌淋巴结转移相关因素的多元分析

被引：42

作者：

张声

李莉

林华

林建银

不详

机构：

[1] 福建医科大学附属第一医院病理科!福州

[2] 福建医科大学分子医学教研室

来源：

中华肿瘤杂志 | 2001年 / 05期

关键词：

胃肿瘤; 淋巴转移; Logistic逐步回归;

D O I：

暂无

中图分类号：

R735.2 [胃肿瘤];

学科分类号：

100214 ;

摘要：

目的　探讨胃癌组织中CD44v6、基质金属蛋白酶 9(MMP 9)、金属蛋白酶抑制剂 1(TIMP 1)和结构型一氧化氮合酶 (cNOS)mRNA的表达等因素与胃癌侵袭转移的关系以及在预测胃癌淋巴结转移中的价值。方法　采用Logistic逐步回归的方法 ,对 119例原发性胃癌 10项与胃癌淋巴结转移有关的指标进行筛选。结果　胃癌组织中CD44v6表达越强 ,发生淋巴结转移的机率越高 ;MMP 9阳性表达而TIMP 1阴性表达者 ,发生淋巴结转移的机率最高 ;MMP 9阴性表达而TIMP 1阳性表达者 ,发生淋巴结转移的机率最低 ;胃癌血管或淋巴管内皮细胞cNOSmRNA阳性表达者 ,发生淋巴结转移的机率较高。结论　胃癌组织中CD44v6表达强度、MMP 9和TIMP 1表达失衡情况及胃癌血管或淋巴管内皮细胞cNOSmRNA的表达情况 ,可作为术前预测患者淋巴结转移的有效指标。

引用

页码：51 / 54

页数：4

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