子宫内膜异位症及其临床治疗策略对育龄期女性卵巢功能的影响

被引：47

作者：

封又荣 ^{[1
]}

魏嘉 ^{[2
]}

付方方 ^{[2
]}

王世宣 ^{[2
]}

吴明富 ^{[2
]}

机构：

[1] 华中科技大学同济医学院

[2] 华中科技大学同济医学院附属同济医院妇产科

来源：

中国妇产科临床杂志 | 2019年 / 20卷 / 05期

关键词：

子宫内膜异位症; 卵巢功能; 卵巢储备; 不孕;

D O I：

10.13390/j.issn.1672-1861.2019.05.038

中图分类号：

R711.71 [子宫内膜异位症];

学科分类号：

100211 [妇产科学];

摘要：

子宫内膜异位症(endometriosis, EMs)是一种雌激素依赖性的炎性疾病,其特征为有活性的子宫内膜组织在子宫腔被覆内膜及子宫以外的部位出现。EMs患者不孕率高达50%。卵巢储备功能下降(diminished ovarian reserve, DOR)可能是EMs相关性不孕症的主要原因。EMs影响卵泡密度及卵子质量,导致卵巢微环境的改变,引起卵巢功能受损和生育功能障碍,不同病理类型EMs影响卵巢功能的机制不同。EMs的临床治疗策略,尤其是卵巢手术对卵巢功能也可产生一定消极影响。因此,对EMs患者早期准确评估卵巢储备并及早干预DOR在临床工作中显得尤为重要。本文主要就子宫内膜异位症及其临床治疗策略对卵巢功能的影响以及卵巢储备的精准评估方法加以综述。

引用

页码：471 / 473

页数：3

共 19 条

[1]

Altered Immunity in Endometriosis: What Came First? [J].

Kralickova, Milena ;

Fiala, Ludek ;

Losan, Petr ;

Tomes, Pavel ;

Vetvicka, Vaclav .

IMMUNOLOGICAL INVESTIGATIONS, 2018, 47 (06) :569-582

[2]

Endometrioma; fertility; and assisted reproductive treatments: connecting the dots.[J].Gustavo N. Cecchino;Juan A. García-Velasco.Current Opinion in Obstetrics and Gynecology.2018,

[3]

Dienogest suppresses the activation of primordial follicles and preserves the primordial follicle stockpile for fertility in mice [J].

Zheng, Luyi ;

Kimura, Fuminori ;

Wu, Di ;

Morimune, Aina ;

Niwa, Yoko ;

Mita, Shizuka ;

Takahashi, Kentaro ;

Murakami, Takashi .

REPRODUCTIVE BIOMEDICINE ONLINE, 2018, 36 (04) :371-379

[4]

Is the oocyte quality affected by endometriosis? A review of the literature.[J].Ana Maria Sanchez;Valeria Stella Vanni;Ludovica Bartiromo;Enrico Papaleo;Eran Zilberberg;Massimo Candiani;Raoul Orvieto;Paola Viganò.Journal of Ovarian Research.2017, 1

[5]

Endometriosis-associated infertility: aspects of pathophysiological mechanisms and treatment options [J].

Tanbo, Tom ;

Fedorcsak, Peter .

ACTA OBSTETRICIA ET GYNECOLOGICA SCANDINAVICA, 2017, 96 (06) :659-667

[6]

Endometriosis as a detrimental condition for granulosa cell steroidogenesis and development: From molecular alterations to clinical impact.[J].Ana Maria Sanchez;Edgardo Somigliana;Paolo Vercellini;Luca Pagliardini;Massimo Candiani;Paola Vigano.Journal of Steroid Biochemistry and Molecular Biology.2016, PA

[7]

Power of Proteomics in Linking Oxidative Stress and Female Infertility.[J].Sajal Gupta;Jana Ghulmiyyah;Rakesh Sharma;Jacques Halabi;Ashok Agarwal;Jeroen Krijgsveld.BioMed Research International.2014,

[8]

Risk factors associated with endometriosis: importance of study population for characterizing disease in the ENDO Study [J].